Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth,
survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to …

Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of
patients with chronic liver disease. Their prevention or reversal have become major …

The high morbidity and mortality of non-small cell lung cancer (NSCLC) have always been
major threats to people's health. With the identification of carcinogenic drivers in non-small …

Tumor progression and dissemination critically depend on support from the tumor
microenvironment, the ensemble of cellular and acellular components surrounding and …

Epithelial-Mesenchymal Transition (EMT) is a critical process in embryonic development in
which epithelial cells undergo a transdifferentiation into mesenchymal cells. This process is …

The extracellular matrix (ECM) is a guiding force that regulates various developmental
stages of the breast. In addition to providing structural support for the cells, it mediates …

The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …

Cell migration and invasion is a key driving factor for providing essential cellular functions
under physiological conditions or the malignant progression of tumors following downward …

Lung cancer is the leading cause of cancer-related deaths worldwide. Despite growing
efforts for its early detection by screening populations at risk, the majority of lung cancer …