CD 38 is a multifunctional cell surface protein that has receptor as well as enzyme functions.
The protein is generally expressed at low levels on various hematological and solid tissues …

The heterogeneity in the healthy human immune system, and the immunological changes
that portend various diseases, have been only partially described. Their comprehensive …

Responses to immunotherapy are uncommon in estrogen receptor (ER)-positive breast
cancer and to date, lack predictive markers. This randomized phase II study defines safety …

Background & Aims Studies are needed to determine the mechanisms of mucosal
dysregulation in patients with inflammatory bowel diseases (IBDs) and differences in …

BACKGROUND. Immune checkpoint blockade is revolutionizing therapy for advanced
cancer, but many patients do not respond to treatment. The identification of robust …

The systemic processes involved in the manifestation of life-threatening COVID-19 and in
disease recovery are still incompletely understood, despite investigations focusing on the …

The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of
enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most …

CD38 is a multifunctional protein widely expressed in cells from the immune system and as
a soluble form in biological fluids. CD38 expression is up-regulated by an array of …

Some rare HIV-1-infected individuals, referred to as HIV controllers (HIC), have persistently
undetectable plasma viral load in the absence of therapy. This control of HIV-1 replication …

Background SARS‐CoV‐2 has triggered a pandemic that is now claiming many lives.
Several studies have investigated cellular immune responses in COVID‐19‐infected …