Liposomes for oral delivery of protein and peptide-based therapeutics: Challenges, formulation strategies, and advances

A Jash, A Ubeyitogullari, SSH Rizvi - Journal of Materials Chemistry B, 2021 - pubs.rsc.org
Throughout the past decade, there has been a rapid growth in the development of
protein/peptide-based therapeutics. These therapeutics have found widespread applications …

[HTML][HTML] Advanced microfluidic technologies for lipid nano-microsystems from synthesis to biological application

BG Carvalho, BT Ceccato, M Michelon, SW Han… - Pharmaceutics, 2022 - mdpi.com
Microfluidics is an emerging technology that can be employed as a powerful tool for
designing lipid nano-microsized structures for biological applications. Those lipid structures …

Ice-inspired lubricated drug delivery particles from microfluidic electrospray for osteoarthritis treatment

L Yang, L Sun, H Zhang, F Bian, Y Zhao - ACS nano, 2021 - ACS Publications
Particle-based drug delivery systems have a demonstrated value in osteoarthritis treatment.
Research in this area trends to developing functional particles to improve the therapeutic …

Preparation of cetyl palmitate-based PEGylated solid lipid nanoparticles by microfluidic technique

I Arduino, Z Liu, A Rahikkala, P Figueiredo, A Correia… - Acta biomaterialia, 2021 - Elsevier
In recent years, several studies have shown that the use of solid lipid nanoparticles (SLN) as
a colloidal drug delivery system was more advantageous than lipid emulsions, liposomes …

Nano and microscale delivery platforms for enhanced oral peptide/protein bioavailability

T Tong, L Wang, X You, J Wu - Biomaterials science, 2020 - pubs.rsc.org
In recent years, peptide/protein drugs have attracted considerable attention owing to their
superior targeting and therapeutic effect and fewer side effects compared with chemical …

[HTML][HTML] Versatile oral insulin delivery nanosystems: from materials to nanostructures

M Wang, C Wang, S Ren, J Pan, Y Wang… - International Journal of …, 2022 - mdpi.com
Diabetes is a chronic metabolic disease characterized by lack of insulin in the body leading
to failure of blood glucose regulation. Diabetes patients usually need frequent insulin …

Microfluidic preparation and in vitro evaluation of iRGD-functionalized solid lipid nanoparticles for targeted delivery of paclitaxel to tumor cells

I Arduino, Z Liu, RM Iacobazzi, AA Lopedota… - International Journal of …, 2021 - Elsevier
Solid lipid nanoparticles (SLNs) can combine the advantages of different colloidal carriers
and prevent some of their disadvantages. The production of nanoparticles by means of …

An overview of oral insulin delivery strategies (OIDS)

G Iyer, S Dyawanapelly, R Jain, P Dandekar - International Journal of …, 2022 - Elsevier
Despite tremendous efforts, the world continues its fight against the common chronic
disease-diabetes. Diabetes is caused by elevated glucose levels in the blood, which can …

Cheerios effect inspired microbubbles as suspended and adhered oral delivery systems

C Zhao, L Cai, M Nie, L Shang, Y Wang… - Advanced …, 2021 - Wiley Online Library
Oral drug administration has an important role in medical treatment. Attempts to develop
drug microcarriers with desired features for extended duration and improved absorption is …

Nanocomposite systems for precise oral delivery of drugs and biologics

V Andretto, A Rosso, S Briançon, G Lollo - Drug delivery and translational …, 2021 - Springer
Oral delivery is considered the favoured route of administration for both local and systemic
delivery of active molecules. Formulation of drugs in conventional systems and …