The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally
identified as a nuclear factor that binds and activates the promoters of type I interferon …

Kaposi sarcoma–associated herpesvirus (KSHV), also known as human herpesvirus 8, is
the etiologic agent underlying Kaposi sarcoma, primary effusion lymphoma, and multicentric …

Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …

B cells orchestrate autoimmune responses in patients with systemic lupus erythematosus
(SLE), but broad-based B cell–directed therapies show only modest efficacy while blunting …

Interferon regulatory factor 8 (IRF8), also known as interferon consensus sequence-binding
protein (ICSBP), is a transcription factor of the IRF family. IRF8 plays a key role in normal B …

Gammaherpesviruses are species-specific, ubiquitous pathogens that establish lifelong
infection in their hosts and are associated with cancers, including B cell lymphomas. Type I …

In mammalian cells, early defenses against infection by pathogens are mounted through a
complex network of signaling pathways shepherded by immune-modulatory pattern …

Gammaherpesviruses (γHVs) are recognized as important pathogens in humans but their
relationship with other animal hosts, especially wildlife species, is less well characterized …

Gammaherpesviruses are highly prevalent pathogens that establish life-long infection and
are associated with diverse malignancies, including lymphoproliferative diseases and B cell …

Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection in> 95% of
adults worldwide and are associated with a variety of malignancies. Coevolution of …