[HTML][HTML] Immunosuppression and liver transplantation

J Lerut, S Iesari - Engineering, 2023 - Elsevier
Perfect surgical techniques and adequate immunosuppression are key to ensuring optimal
graft and patient survival. The availability of different drugs has led to several, often industry …

Viability criteria during liver ex-situ normothermic and hypothermic perfusion

F Melandro, R De Carlis, F Torri, A Lauterio… - Medicina, 2022 - mdpi.com
With the increased use of extended-criteria donors, machine perfusion became a beneficial
alternative to cold storage in preservation strategy for donor livers with the intent to expand …

Assessing donor liver quality and restoring graft function in the era of extended criteria donors

Y Lin, H Huang, L Chen, R Chen, J Liu… - Journal of Clinical …, 2022 - pmc.ncbi.nlm.nih.gov
Liver transplantation (LT) is the final treatment option for patients with end-stage liver
disease. The increasing donor shortage results in the wide usage of grafts from extended …

Liver transplantation immunology: Immunosuppression, rejection, and immunomodulation

AJ Montano-Loza, ML Rodríguez-Perálvarez… - Journal of …, 2023 - Elsevier
Outcomes after liver transplantation have continuously improved over the past decades, but
long-term survival rates are still lower than in the general population. The liver has distinct …

The chromatin remodeling protein BRG1 contributes to liver ischemia-reperfusion injury by regulating NOXA expression

N Li, H Liu, Y Xue, Q Zhu, Z Fan - Life Sciences, 2023 - Elsevier
Aims Hepatic ischemia-reperfusion injury (IRI) is a common complication secondary to liver
transplantation. Extensive death of hepatocytes, typically in the form of apoptosis, is …

cGAS–STING pathway in ischemia-reperfusion injury: a potential target to improve transplantation outcomes

Z Chen, Y Liu, Z Lin, W Huang - Frontiers in Immunology, 2023 - frontiersin.org
Transplantation is an important life-saving therapeutic choice for patients with organ or
tissue failure once all other treatment options are exhausted. However, most allografts …

[HTML][HTML] Immunology demystified: A guide for transplant hepatologists

I Kosuta, T Kelava, A Ostojic, V Sesa… - World Journal of …, 2024 - ncbi.nlm.nih.gov
Liver transplantation has become standard practice for treating end-stage liver disease. The
success of the procedure relies on effective immunosuppressive medications to control the …

[PDF][PDF] Donor-derived cell-free DNA-based liquid biopsies to determine future kidney transplant rejection

W Wang, CG Haider, Y Wang, Z Zhang… - Kidney research and …, 2024 - researchgate.net
Donor-derived cell-free DNA (dd-cfDNA) based liquid kidney biopsies have the potential to
detect the chances of kidney transplant rejection. Several studies have found that dd-cfDNA …

Liver transplantation and dd-cfDNA: A small solution for a big problem

E Avramidou, S Vasileiadou, N Antoniadis, G Katsanos… - Livers, 2023 - mdpi.com
Dd-cfDNA is a novel biomarker with many diagnostic applications in various areas of
medicine. In this review of the literature, we investigate its role in the diagnosis of many …

[HTML][HTML] Circulating, cell-free methylated DNA indicates cellular sources of allograft injury after liver transplant

ME McNamara, SS Jain, K Oza, V Muralidaran, AJ Kiliti… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Post-transplant complications reduce allograft and recipient survival. Current approaches for
detecting allograft injury non-invasively are limited and do not differentiate between cellular …