Rapid progress in the field of microfluidics coupled with increase in demand for cell
separation techniques for biomedical diagnostics has gained significant attention among …

As populations age across the world, osteoporosis and osteoporosis-related fractures are
becoming the most prevalent degenerative bone diseases. More than 75 million patients …

Introduction Low back pain (LBP) is a global health concern. Increasing evidence implicates
intervertebral disk (IVD) degeneration as a major contributor. In this respect, tissue‐specific …

Previous work showed a link between Tie2+ nucleus pulposus progenitor cells (NPPC) and
disc degeneration. However, NPPC remain difficult to maintain in culture. Here, we report …

Loss of refreshment in nucleus pulposus (NP) cellularity leads to intervertebral disc (IVD)
degeneration. Nevertheless, the cellular sequence of NP cell differentiation remains unclear …

Modern methods have evolved in tissue engineering to evaluate cell viability (CV) in 3D
scaffolds and tissues. These involve either the usage of 3D confocal laser microscopy of live …

Lower back pain is a leading cause of disability worldwide. The recovery of nucleus
pulposus (NP) progenitor cells (NPPCs) from the intervertebral disc (IVD) holds high …

Introduction: Low back pain (LBP) is a significant cause of disability in many countries,
affecting more than half a billion people worldwide. In the past, progenitor cells have been …

Intervertebral Disc Degeneration (IDD) is recognized as an aging process, an important and
most common pathological condition caused by an imbalance of anabolic and catabolic …

After the discovery of functionally superior Tie2-positive nucleus pulposus (NP) progenitor
cells, new methods were needed to enable mass culture and cryopreservation to maintain …