Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

The integration of β-barrel proteins into the bacterial outer membrane (OM) is catalysed by
the β-barrel assembly machinery (BAM). The central BAM subunit (BamA) itself contains a β …

Transmembrane β barrel proteins are folded into the outer membrane (OM) of Gram-
negative bacteria by the β barrel assembly machinery (BAM) via a poorly understood …

β‐barrel membrane proteins in the mitochondrial outer membrane are crucial for mediating
the metabolite exchange between the cytosol and the mitochondrial intermembrane space …

The vast majority of theoretically possible polypeptide chains do not fold, let alone confer
function. Hence, protein evolution from preexisting building blocks has clear potential …

Natural evolution has generated an impressively diverse protein universe via duplication
and recombination from a set of protein fragments that served as building blocks. The …

Life on Earth is driven by electron transfer reactions catalyzed by a suite of enzymes that
comprise the superfamily of oxidoreductases (Enzyme Classification EC1). Most modern …

Periplasmic chaperones 17-kilodalton protein (Skp) and survival factor A (SurA) are
essential players in outer membrane protein (OMP) biogenesis. They prevent unfolded …

Salmonella is an important pathogen causing food poisoning. Food safety and health are
the themes of today′ s society. As a class of food-borne pathogens, Salmonella enteritidis …

Highlights•Sub-domain segments may carry hints to the evolution of protein
domains.•Similar sub-domain segments shared among globally dissimilar domains are …