Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40
years ago. Since that time, remarkable progress has been made in understanding its …

Skin injury is a common occurrence and mechanical forces are known to significantly impact
the biological processes of skin regeneration and wound healing. Immediately following the …

Melanoma is a cutaneous neoplastic growth of melanocytes with great potential to invade
and metastasize, especially when not treated early and effectively. Epithelial-mesenchymal …

The Koebner phenomenon, also known as isomorphic reaction, refers to the development of
secondary lesions with the same clinical manifestations and histopathological …

Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple
intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As …

The shaping of a multicellular body and repair of adult tissues require fine-tuning of cell
adhesion, cell mechanics, and intercellular transmission of mechanical load. Adherens …

Cell–cell adhesions are necessary for structural integrity and barrier formation of the
epidermis. Here, we discuss insights from genetic and cell biological studies into the roles of …

The molecular mechanisms by which physical forces control tissue development are
beginning to be elucidated. Sites of adhesion between both cells and the extracellular …

In the process of mechanotransduction, the cells in the body perceive and interpret
mechanical stimuli to maintain tissue homeostasis and respond to the environmental …