“Stripe” transcription factors provide accessibility to co-binding partners in mammalian genomes
Regulatory elements activate promoters by recruiting transcription factors (TFs) to specific
motifs. Notably, TF-DNA interactions often depend on cooperativity with colocalized …
motifs. Notably, TF-DNA interactions often depend on cooperativity with colocalized …
Identifying oligodendrocyte enhancers governing Plp1 expression
Oligodendrocytes (OLs) produce myelin in the central nervous system (CNS), which
accelerates the propagation of action potentials and supports axonal integrity. As a major …
accelerates the propagation of action potentials and supports axonal integrity. As a major …
Uncovering oligodendrocyte enhancers that control Cnp expression
Oligodendrocytes (OLs) produce myelin sheaths around axons in the central nervous
system (CNS). Myelin accelerates the propagation of action potentials along axons and …
system (CNS). Myelin accelerates the propagation of action potentials along axons and …
MYRF: A unique transmembrane transcription factor‐from proteolytic self‐processing to its multifaceted roles in animal development
YB Qi, Z Xu, S Shen, Z Wang, Z Wang - BioEssays, 2024 - Wiley Online Library
Abstract The Myelin Regulator Factor (MYRF) is a master regulator governing myelin
formation and maintenance in the central nervous system. The conservation of MYRF across …
formation and maintenance in the central nervous system. The conservation of MYRF across …
Identifying an oligodendrocyte enhancer that regulates Olig2 expression
Olig2 is a basic helix–loop–helix transcription factor that plays a critical role in the central
nervous system. It directs the specification of motor neurons and oligodendrocyte precursor …
nervous system. It directs the specification of motor neurons and oligodendrocyte precursor …
[PDF][PDF] RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression
W Mu, NS Murcia, KN Smith, DU Menon, D Yee… - G3, 2022 - academic.oup.com
RBBP4 is a subunit of the chromatin remodeling complexes known as Polycomb repressive
complex 2 and histone deacetylase 1/2-containing complexes. These complexes are …
complex 2 and histone deacetylase 1/2-containing complexes. These complexes are …
Species-specific sensitivity to TGFβ signaling and changes to the Mmp13 promoter underlie avian jaw development and evolution
Precise developmental control of jaw length is critical for survival, but underlying molecular
mechanisms remain poorly understood. The jaw skeleton arises from neural crest …
mechanisms remain poorly understood. The jaw skeleton arises from neural crest …
Enhanced differentiation of the mouse oli-neu oligodendroglial cell line using optimized culture conditions
GR Bey, QS Padiath - BMC Research Notes, 2023 - Springer
Objective Oligodendrocytes (OL) are the glial cell type in the CNS that are responsible for
myelin formation. The ability to culture OLs in vitro has provided critical insights into the …
myelin formation. The ability to culture OLs in vitro has provided critical insights into the …
A systematic strategy for identifying causal single nucleotide polymorphisms and their target genes on juvenile arthritis risk haplotypes
Background Although genome-wide association studies (GWAS) have identified multiple
regions conferring genetic risk for juvenile idiopathic arthritis (JIA), we are still faced with the …
regions conferring genetic risk for juvenile idiopathic arthritis (JIA), we are still faced with the …
Molecular mechanism for the multiple sclerosis risk variant rs17594362
Multiple sclerosis (MS) is known as an autoimmune demyelinating disease of the central
nervous system. However, its cause remains elusive. Given previous studies suggesting that …
nervous system. However, its cause remains elusive. Given previous studies suggesting that …