Allenes are a class of unique compounds with two π-orbitals perpendicular to each other.
The first synthesis can be traced back to 1887. 1 They also exist in many natural products …

The Pauson±Khand (P±K) reaction, formally a [21211] cycloaddition involving an alkene, an
alkyne and carbon monoxide moieties to form a cyclopentenone, was first discovered in the …

Allenes have allowed chemists to access a variety of structurally interesting and biologically
active products. The emergence of these unique compounds in organic synthesis is a direct …

Covering: 2000–2018 In this review, we highlight recent examples of natural product total
syntheses employing transition metal-mediated/catalyzed carbonylative cyclization …

The [2+ 2+ 1] cyclization of an alkyne, an alkene and carbon monoxide, ie, the Pauson–
Khand reaction, is one of the most powerful tools for constructing a five-membered ring. In …

It has been 60 years since Eschenmoser and Frey disclosed the archetypal C C
fragmentation reaction. New fragmentations and several variants of the original quickly …

An asymmetric total synthesis of (−)-spirochensilide A has been achieved for the first time.
The synthesis features a semipinacol rearrangement reaction to stereoselectively construct …

A rhodium carbonyl complex,[RhCl (CO) 2] 2, serves as a catalyst of the intra-and inter-
molecular Pauson–Khand reaction. By the use of the rhodium catalyst, cyclopentenone …

Treatment of alkynyl allenes with [Rh (CO) 2Cl] 2 results in a formal [2+ 2+ 1] cycloaddition
reaction. This reaction occurs with complete regioselectivity for a variety of substrates …

(AOR) or leukotriene B4 12-hydroxydehydrogenase, reductively activates AFs. 54 AFs
interact with redox-modulating enzymes, such as glutathione reductase (GR), thioredoxin …