Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

Carcinogenesis is a multistep process involving mutation and the subsequent selective
clonal expansion of the mutated cell. Chemical and physical agents including those that …

Oxidative stress is characterized by imbalanced reactive oxygen species (ROS) production
and antioxidant defenses. Two main antioxidant systems exist. The nonenzymatic system …

Reactive oxygen species (ROS) are induced through a variety of endogenous and
exogenous sources. Overwhelming of antioxidant and DNA repair mechanisms in the cell by …

Catalase (CAT) is a well-studied enzyme that plays an important role in protecting cells
against the toxic effects of hydrogen peroxide. In human, it has been implicated in different …

The presence and progression of numerous diseases have been linked to deficiencies in
antioxidant systems. The relationships between single nucleotide polymorphisms (SNPs) …

Prostate cancer has the highest prevalence of any non-cutaneous cancer in the human body
and essentially all men with circulating androgens will develop microscopic prostate cancer …

The relevance of reactive oxygen species (ROS) production relies on the dual role shown by
these molecules in aerobes. ROS are known to modulate several physiological phenomena …

Abstract Glutathione peroxidase 1 (GPX1) is a ubiquitously expressed selenium-dependent
enzyme that protects cells against oxidative damage by reducing hydrogen peroxide and a …

Iron overload may increase prostate cancer risk through stimulation of oxidative stress, and
endogenous pro-and antioxidant capabilities, ie manganese superoxide dismutase …