In pursuit of next-generation therapeutics: Antimicrobial peptides against superbugs, their sources, mechanism of action, nanotechnology-based delivery, and clinical …

A Thakur, A Sharma, HK Alajangi, PK Jaiswal… - International Journal of …, 2022 - Elsevier
Antimicrobial peptides (AMPs) attracted attention as potential source of novel antimicrobials.
Multi-drug resistant (MDR) infections have emerged as a global threat to public health in …

Defensins: antifungal lessons from eukaryotes

PM Silva, S Gonçalves, NC Santos - Frontiers in microbiology, 2014 - frontiersin.org
Over the last years, antimicrobial peptides (AMPs) have been the focus of intense research
toward the finding of a viable alternative to current antifungal drugs. Defensins are one of the …

Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: assessment of geographic variation and its implication on snakebite management

J Boldrini-França, C Corrêa-Netto, MMS Silva… - Journal of …, 2010 - Elsevier
We report the comparative proteomic and antivenomic characterization of the venoms of
subspecies cascavella and collilineatus of the Brazilian tropical rattlesnake Crotalus …

Intraspecific venom variation in the medically significant Southern Pacific Rattlesnake (Crotalus oreganus helleri): biodiscovery, clinical and evolutionary implications

K Sunagar, EAB Undheim, H Scheib, ECK Gren… - Journal of …, 2014 - Elsevier
Due to the extreme variation of venom, which consequently results in drastically variable
degrees of neutralization by CroFab antivenom, the management and treatment of …

Polypeptides from traditional Chinese medicine: Comprehensive review of perspective towards cancer management

Z Jia, X Zhu, Y Zhou, J Wu, M Cao, C Hu, L Yu… - International Journal of …, 2024 - Elsevier
Cancer has always been a focus of global attention, and the difficulty of treatment and poor
prognosis have always plagued humanity. Conventional chemotherapeutics and treatment …

Application of molecular dynamic simulation to study food proteins: A review

A Singh, SK Vanga, V Orsat… - Critical reviews in food …, 2018 - Taylor & Francis
This review presents an overview of the application of molecular dynamic simulation to study
food proteins. Processing of food using thermal, chemical, radiation, electromagnetic, and …

Cytotoxic and antitumor peptides as novel chemotherapeutics

X Luan, Y Wu, YW Shen, H Zhang, YD Zhou… - Natural product …, 2021 - pubs.rsc.org
Covering: up to 2020 Treatment resistance and drug-induced refractory malignancies pose
significant challenges for current chemotherapy drugs. There have been increasing …

Crotamine mediates gene delivery into cells through the binding to heparan sulfate proteoglycans

FD Nascimento, MAF Hayashi, A Kerkis… - Journal of Biological …, 2007 - ASBMB
Recently we have shown that crotamine, a toxin from the South American rattlesnake
Crotalus durissus terrificus venom, belongs to the family of cell-penetrating peptides …

[HTML][HTML] Unraveling the antifungal activity of a South American rattlesnake toxin crotamine

ES Yamane, FC Bizerra, EB Oliveira, JT Moreira… - Biochimie, 2013 - Elsevier
Crotamine is a highly basic peptide from the venom of Crotalus durissus terrificus
rattlesnake. Its common gene ancestry and structural similarity with the β-defensins, mainly …

Snake venom peptides and low mass proteins: molecular tools and therapeutic agents

JR Almeida, LM Resende, RK Watanabe… - Current medicinal …, 2017 - ingentaconnect.com
Snake venoms are natural sources of biologically active molecules that are able to act
selectively and specifically on different cellular targets, modulating physiological functions …