Unmasking the subtleties of the immune system requires both a comprehensive knowledge
base and the ability to interrogate that system with intimate sensitivity. That task, to a …

T cells are at the center of cancer immunology because of their ability to recognize mutations
in tumor cells and directly mediate cancer cell killing. Immunotherapies to rejuvenate …

Evidence suggests that innate and adaptive cellular responses mediate resistance to the
influenza virus and confer protection after vaccination. However, few studies have resolved …

Immunotherapies have achieved remarkable successes in the treatment of cancer, but major
challenges remain,. An inherent weakness of current treatment approaches is that …

Ageing of the immune system is characterized by decreased lymphopoiesis and adaptive
immunity, and increased inflammation and myeloid pathologies,. Age-related changes in …

The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely
correlated with the cellular availability of glucose. When glucose levels are low, the …

Glycolytic intermediary metabolites such as fructose-1, 6-bisphosphate can serve as signals,
controlling metabolic states beyond energy metabolism. However, whether glycolytic …

Severe COVID-19 causes profound immune perturbations, but pre-infection immune
signatures contributing to severe COVID-19 remain unknown. Genome-wide association …

High‐dimensional immunoprofiling is essential for studying host response to
immunotherapy, infection, and disease in murine model systems. However, the difficulty of …

Single-cell technologies can measure the expression of thousands of molecular features in
individual cells undergoing dynamic biological processes. While examining cells along a …