AlphaFold2 and its applications in the fields of biology and medicine
Z Yang, X Zeng, Y Zhao, R Chen - Signal Transduction and Targeted …, 2023 - nature.com
Abstract AlphaFold2 (AF2) is an artificial intelligence (AI) system developed by DeepMind
that can predict three-dimensional (3D) structures of proteins from amino acid sequences …
that can predict three-dimensional (3D) structures of proteins from amino acid sequences …
Molecular panorama of therapy resistance in prostate cancer: a pre-clinical and bioinformatics analysis for clinical translation
Prostate cancer (PCa) is a malignant disorder of prostate gland being asymptomatic in early
stages and high metastatic potential in advanced stages. The chemotherapy and surgical …
stages and high metastatic potential in advanced stages. The chemotherapy and surgical …
Macrophage barrier in the tumor microenvironment and potential clinical applications
S Ji, Y Shi, B Yin - Cell Communication and Signaling, 2024 - Springer
The tumor microenvironment (TME) constitutes a complex microenvironment comprising a
diverse array of immune cells and stromal components. Within this intricate context, tumor …
diverse array of immune cells and stromal components. Within this intricate context, tumor …
Glioblastoma glycolytic signature predicts unfavorable prognosis, immunological heterogeneity, and ENO1 promotes microglia M2 polarization and cancer cell …
Glioblastomas are the most malignant brain tumors, whose progress was promoted by
aberrate aerobic glycolysis. The immune environment was highly engaged in glioblastoma …
aberrate aerobic glycolysis. The immune environment was highly engaged in glioblastoma …
LncRNA RARA-AS1 could serve as a novel prognostic biomarker in pan-cancer and promote proliferation and migration in glioblastoma
Y Huang, S Deng, Q Jiang, J Shi - Scientific Reports, 2023 - nature.com
Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of cancer
progression and are potential biomarkers for diagnosis and treatment. This study …
progression and are potential biomarkers for diagnosis and treatment. This study …
CEP55 as a Promising Immune Intervention Marker to Regulate Tumor Progression: A Pan-Cancer Analysis with Experimental Verification
G Wang, B Chen, Y Su, N Qu, D Zhou, W Zhou - Cells, 2023 - mdpi.com
CEP55, a member of the centrosomal protein family, affects cell mitosis and promotes the
progression of several malignancies. However, the relationship between CEP55 expression …
progression of several malignancies. However, the relationship between CEP55 expression …
Crosstalk between colorectal CSCs and immune cells in tumorigenesis, and strategies for targeting colorectal CSCs
Q Zhao, H Zong, P Zhu, C Su, W Tang, Z Chen… - … Hematology & Oncology, 2024 - Springer
Cancer immunotherapy has emerged as a promising strategy in the treatment of colorectal
cancer, and relapse after tumor immunotherapy has attracted increasing attention. Cancer …
cancer, and relapse after tumor immunotherapy has attracted increasing attention. Cancer …
[HTML][HTML] In Silico Analysis Uncovers FOXA1 as a Potential Biomarker for Predicting Neoadjuvant Chemotherapy Response in Fine-Needle Aspiration Biopsies
Z Yin, J Tao, Y Liu, H Chen, K Hu, Y Wang… - Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Background: The preoperative identification of neoadjuvant chemotherapy (NAC) treatment
responsiveness in breast cancer (BC) patients is advantageous for tailoring treatment …
responsiveness in breast cancer (BC) patients is advantageous for tailoring treatment …
The prognostic and immunological role of MCM3 in pan-cancer and validation of prognosis in a clinical lower-grade glioma cohort
QR Huang, Q Jiang, JY Tan, RB Nong, J Yan… - Frontiers in …, 2024 - frontiersin.org
Background: Previous studies have shown that MCM3 plays a key role in initiating DNA
replication. However, the mechanism of MCM3 function in most cancers is still unknown. The …
replication. However, the mechanism of MCM3 function in most cancers is still unknown. The …
Identification of CREB5 as a prognostic and immunotherapeutic biomarker in glioma through multi-omics pan-cancer analysis
Z Wu, X Wang, H Wu, S Du, Z Wang, S Xie… - Computers in Biology …, 2024 - Elsevier
Background The functional relevance of cyclic adenosine monophosphate (cAMP)-response
element-binding protein 5 (CREB5) in cancers remains elusive, despite its significance as a …
element-binding protein 5 (CREB5) in cancers remains elusive, despite its significance as a …