[HTML][HTML] The IL-1 cytokine family as custodians of barrier immunity

L Matarazzo, YEH Santana, PT Walsh, PG Fallon - Cytokine, 2022 - Elsevier
Abstract The interleukin-1 (IL-1) family of cytokines and receptors are implicated in the
functioning of innate and adaptive immunity and the genesis of inflammation. They are …

The role of the interleukin-36 axis in generalized pustular psoriasis: a review of the mechanism of action of spesolimab

JE Hawkes, S Visvanathan, JG Krueger - Frontiers in Immunology, 2023 - frontiersin.org
Generalized pustular psoriasis (GPP) is a rare, chronic, inflammatory skin disorder
characterized by recurrent flares associated with skin erythema, desquamation, and …

Pro-and anti-inflammatory roles of interleukin (IL)-33, IL-36, and IL-38 in inflammatory bowel disease

A Andoh, A Nishida - Journal of Gastroenterology, 2023 - Springer
Abstract Interleukin-33 (IL-33), IL-36, and IL-38 are members of the IL-1 cytokine family. The
expression of each cytokine has been reported to be increased in the inflamed mucosa of …

Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/IL …

KJ Baker, E Brint, A Houston - British Journal of Cancer, 2023 - nature.com
Abstract Background The interleukin (IL)-36 cytokines are a sub-family of the IL-1 family
which are becoming increasingly implicated in the pathogenesis of inflammatory diseases …

Phytocannabinoids Reduce Inflammation of Primed Macrophages and Enteric Glial Cells: An In Vitro Study

G Cohen, O Gover, B Schwartz - International Journal of Molecular …, 2023 - mdpi.com
Intestinal inflammation is mediated by a subset of cells populating the intestine, such as
enteric glial cells (EGC) and macrophages. Different studies indicate that phytocannabinoids …

IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells

G Leon, YE Hernandez Santana, N Irwin… - Mucosal …, 2022 - nature.com
IL-36 cytokines are emerging as potent orchestrators of intestinal inflammation and are
being implicated in the pathogenesis of inflammatory bowel diseases (IBD). However, the …

IL-36α/IL-36RA/IL-38 signaling mediates inflammation and barrier disruption in human corneal epithelial cells under hyperosmotic stress

JM Li, R Lu, Y Zhang, J Lin, X Hua, SC Pflugfelder… - The ocular …, 2021 - Elsevier
Abstracts Purpose To explore the distinct expression and diverse roles of IL-36 cytokines in
dry eye disease using an in vitro hyperosmolarity model of human corneal epithelial cells …

IL-36 signalling enhances a pro-tumorigenic phenotype in colon cancer cells with cancer cell growth restricted by administration of the IL-36R antagonist

K Baker, C O'Donnell, M Bendix, S Keogh, J Byrne… - Oncogene, 2022 - nature.com
The IL-36 cytokines are a recently described subset of the IL-1 family of cytokines, shown to
play a role in the pathogenesis of intestinal diseases such as Inflammatory Bowel Disease …

Interleukin-36β exacerbates DSS-induce acute colitis via inhibiting Foxp3+ regulatory T cell response and increasing Th2 cell response

J Zhu, Y Xu, Z Li, S Liu, W Fu, Y Wei - International Immunopharmacology, 2022 - Elsevier
Abstract Background interleukin (IL)-36β is a member of the IL-36 subfamily of the IL-1
family. Usually, serum levels of IL-36β are higher in patients with inflammatory bowel …

Interleukin‐1 family cytokines at the crossroads of microbiome regulation in barrier health and disease

P Narros‐Fernández… - The FEBS …, 2024 - Wiley Online Library
Recent advances in understanding how the microbiome can influence both the physiology
and the pathogenesis of disease in humans have highlighted the importance of gaining a …