The therapeutic potential of stem cell-derived exosomes in the ulcerative colitis and colorectal cancer

G Guo, Z Tan, Y Liu, F Shi, J She - Stem cell research & therapy, 2022 - Springer
Abstract Background Mesenchymal stem cells (MSCs) therapy is a novel treatment strategy
for cancer and a wide range of diseases with an excessive immune response such as …

The dual role of mesenchymal stem cells in cancer pathophysiology: pro-tumorigenic effects versus therapeutic potential

Y Slama, F Ah-Pine, M Khettab, A Arcambal… - International Journal of …, 2023 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) are multipotent cells involved in numerous
physiological events, including organogenesis, the maintenance of tissue homeostasis …

Glioblastoma-associated microglia reprogramming is mediated by functional transfer of extracellular miR-21

ER Abels, SLN Maas, L Nieland, Z Wei, PS Cheah… - Cell reports, 2019 - cell.com
Gliomas are primary, diffusely infiltrating brain tumors. Microglia are innate immune cells in
the CNS and make up a substantial portion of the tumor mass. Glioma cells shape their …

Bone marrow mesenchymal stem cell-derived exosomal miR-21 protects C-kit+ cardiac stem cells from oxidative injury through the PTEN/PI3K/Akt axis

B Shi, Y Wang, R Zhao, X Long, W Deng, Z Wang - PLoS One, 2018 - journals.plos.org
Stem cell (SC) therapy for ischemic cardiomyopathy is hampered by poor survival of the
implanted cells. Recently, SC-derived exosomes have been shown to facilitate cell …

MicroRNA-21 down-regulates inflammation and inhibits periodontitis

W Zhou, L Su, X Duan, X Chen, A Hays… - Molecular …, 2018 - Elsevier
Periodontitis is one of the most prevalent inflammatory diseases, characterized by gingival
inflammation and alveolar bone loss. MicroRNAs (MiRNAs) are important regulators of …

Epigenetic regulation of mesenchymal stem cell homeostasis

BD Sui, CX Zheng, M Li, Y Jin, CH Hu - Trends in Cell Biology, 2020 - cell.com
Mesenchymal stem cells (MSCs) have putative roles in maintaining adult tissue health, and
the functional decline of MSCs has emerged as a crucial pathophysiological driver of …

MicroRNA‐22 promotes renal tubulointerstitial fibrosis by targeting PTEN and suppressing autophagy in diabetic nephropathy

Y Zhang, S Zhao, D Wu, X Liu, M Shi… - Journal of diabetes …, 2018 - Wiley Online Library
Renal tubulointerstitial fibrosis (TIF) is a major feature of diabetic nephropathy (DN). There is
increasing evidence demonstrating that microRNAs act as key players in the regulation of …

Bidirectional regulation of osteogenic differentiation by the FOXO subfamily of Forkhead transcription factors in mammalian MSCs

D Chen, Y Gong, L Xu, M Zhou, J Li, J Song - Cell proliferation, 2019 - Wiley Online Library
Through loss‐and gain‐of‐function experiments in knockout and transgenic mice, Forkhead
box O (FOXO) family transcription factors have been demonstrated to play essential roles in …

microRNA-21 contributes to orthodontic tooth movement

N Chen, BD Sui, CH Hu, J Cao… - Journal of dental …, 2016 - journals.sagepub.com
microRNAs could be mechanosensitive and emerge as critical posttranscriptional regulators
in the bone-remodeling process. During orthodontic tooth movement (OTM), the application …

Regulatory B cells improve ventricular remodeling after myocardial infarction by modulating monocyte migration

J Jiao, S He, Y Wang, Y Lu, M Gu, D Li, T Tang… - Basic research in …, 2021 - Springer
Overactivated inflammatory responses contribute to adverse ventricular remodeling after
myocardial infarction (MI). Regulatory B cells (Bregs) are a newly discovered subset of B …