The two main components of a tissue engineered device are the transplanted cells and the
biomaterial, creating a device for the restoration or modification of tissue or organ function …

Hypothesis: Is renal allograft rejection initiated by the response to injury sustained during the
transplant process? Allograft rejection can be caused by numerous factors such as damage …

For many years the direct stimulation of T cells in response to donor MHC antigens
expressed on donor antigen-presenting cells has been the focus of transplantation …

Chronic rejection has been the major obstacle to the long-term allograft survival in the clinic.
Although the etiology of this rejection reaction is multifactorial, alloantigen-specific immune …

The principal targets of the immune response to allografts are the major histocompatibility
complex (MHC) molecules, and T cell recognition of allo-MHC is the primary and central …

Laboratory of Immunogenetics and Transplantation, Brigham and Women's Hospital and
Harvard Medical School, Boston, Massachusetts, USA renal transplant dysfunction, as …

Transplant surgery injury recruits recipient MHC class II-positive leukocytes into the kidney.
Background CD4 T cells, which are stimulated by the “indirect pathway” of antigen …

Methods. Lewis recipients of fully mismatched Wistar Furth cardiac allografts were
immunized before transplantation with donor MHC allopeptides. Results. Animals …

New insights into the mechanisms of allorecognition and the interactions of the TCR with the
MHC molecule—peptide complex on antigen presenting cells have focused attention on …

Background. Late acute rejection affects up to 28% of renal allograft recipients and remains
a major risk factor for late graft loss. As donor-origin antigen-presenting cells are depleted …