Current development of 1, 2, 3-triazole derived potential antimalarial scaffolds: Structure activity relationship (SAR) and bioactive compounds

SMA Rahman, JS Bhatti, S Thareja, V Monga - European Journal of …, 2023 - Elsevier
Malaria is among one of the most devastating and deadliest parasitic disease in the world
claiming millions of lives every year around the globe. It is a mosquito-borne infectious …

Indigenous uses, phytochemical analysis, and anti-inflammatory properties of Australian tropical medicinal plants

K Yeshi, G Turpin, T Jamtsho, P Wangchuk - Molecules, 2022 - mdpi.com
Australian tropical plants have been a rich source of food (bush food) and medicine to the
first Australians (Aboriginal people), who are believed to have lived for more than 50,000 …

Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products

T Jamtsho, K Yeshi, MJ Perry, A Loukas, P Wangchuk - Pharmaceuticals, 2024 - mdpi.com
Natural products (NPs) have played a vital role in human survival for millennia, particularly
for their medicinal properties. Many traditional medicine practices continue to utilise crude …

Antifungal activity and potential action mechanism of allicin against Trichosporon asahii

X Yang, S Bai, J Wu, Y Fan, Y Zou, Z Xia… - Microbiology …, 2023 - Am Soc Microbiol
Trichosporon asahii is an emerging opportunistic pathogen that causes potentially fatal
disseminated trichosporonosis. The global prevalence of coronavirus disease 2019 (COVID …

Detection of Crimean-Congo hemorrhagic fever virus antibodies in cattle in Plateau State, Nigeria

AA Dzikwi-Emennaa, C Meseko, P Emennaa… - Viruses, 2022 - mdpi.com
Crimean-Congo hemorrhagic fever (CCHF) is a vector-borne viral hemorrhagic disease with
global clinical significance. Certain species of ticks are vectors of CCHF, which can be …

Sesquiterpene Lactones with Dual Inhibitory Activity against the Trypanosoma brucei Pteridine Reductase 1 and Dihydrofolate Reductase

K Possart, FC Herrmann, J Jose, MP Costi, TJ Schmidt - Molecules, 2021 - mdpi.com
The parasite Trypanosoma brucei (T. brucei) is responsible for human African
trypanosomiasis (HAT) and the cattle disease “Nagana” which to this day cause severe …

Therapeutic Potential of Natural Products in the Treatment of Schistosomiasis

CM Azevedo, CS Meira, JW da Silva, DMN Moura… - Molecules, 2023 - mdpi.com
It is estimated that 250 million people worldwide are affected by schistosomiasis. Disease
transmission is related to the poor sanitation and hygiene habits that affect residents of …

Natural Perylenequinone Compounds as Potent Inhibitors of Schistosoma mansoni Glutathione S-Transferase

B Otarigho, MO Falade - Life, 2023 - mdpi.com
The existing treatment strategy for Schistosomiasis centers on praziquantel, a single drug,
but its effectiveness is limited due to resistance and lack of preventive benefits. Thus, there is …

Natural products for the treatment of hypertrophic scars: preclinical and clinical studies

Y Zhang, E Liu, H Gao, Q He, A Chen, Y Pang, X Zhang… - Heliyon, 2024 - cell.com
Hypertrophic scarring (HS) is a complication of wound healing that causes physiological and
psychological distress in patients. However, the possible mechanism underlying HS is not …

In Silico and In Vitro Search for Dual Inhibitors of the Trypanosoma brucei and Leishmania major Pteridine Reductase 1 and Dihydrofolate Reductase

K Possart, FC Herrmann, J Jose, TJ Schmidt - Molecules, 2023 - mdpi.com
The parasites Trypanosoma brucei (Tb) and Leishmania major (Lm) cause the tropical
diseases sleeping sickness, nagana, and cutaneous leishmaniasis. Every year, millions of …