Cuproptosis is a novel type of copper-induced cell death that primarily occurs in cells that
utilize oxidative phosphorylation as the main metabolic pathway to produce energy. Copper …

TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …

The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Breast cancer is one of the most common malignancy among women worldwide. Metastasis
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …

The function of p53 as a tumour suppressor has been attributed to its ability to promote cell
death or permanently inhibit cell proliferation. However, in recent years, it has become clear …

Abstract p53 plays a key role in tumor suppression. The tumor suppressive function of p53
has long been attributed to its ability to induce apoptosis, cell cycle arrest, and senescence …

Cancer cells acquire distinct metabolic adaptations to survive stress associated with tumour
growth and to satisfy the anabolic demands of proliferation. The tumour suppressor protein …

Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H 2 O
2) are thought to be byproducts of aerobic respiration with damaging effects on DNA …