Zinc (Zn) is one of the most important essential nutrients of great public health significance. It
is involved in numerous biological functions and it is considered as a multipurpose trace …

The extracellular matrix (ECM) is a macromolecules network, in which the most abundant
molecule is collagen. This protein in triple helical conformation is highly resistant to …

Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous
concern in every transplantation proceeding, from whole organs to modest grafts. Given its …

Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Matrix metalloproteinases (MMPs) are a large family of enzymes that degrade the
extracellular matrix (ECM). Under pathologic conditions, overexpression of MMPs or …

The posttranslational proteolytic cleavage is a unique and irreversible process that governs
the function and half-life of numerous proteins. Thereby the role of the family of A disintegrin …

Matrix metalloproteinases (MMPs) are endopeptidases participating in physiological
processes of the brain, maintaining the blood–brain barrier integrity and playing a critical …

Matrix metalloproteinases are enzymes that degrade the extracellular matrix. They have
different substrates but similar structural organization. Matrix metalloproteinases are …

Collagen is the most abundant protein in mammals, often serving as the main load bearing
constituent in soft tissues. Collagen undergoes continuous remodeling processes in which …

Osteoarthritis (OA) is a chronic musculoskeletal disorder characterized by an imbalance
between (synthesis) and catabolism (degradation) in altered homeostasis of articular …