Photodynamic therapy (PDT) is a clinical modality used to treat cancer and infectious
diseases. The main agent is the photosensitizer (PS), which is excited by light and converted …

The use of non-toxic dyes or photosensitizers (PS) in combination with harmless visible light
that is known as photodynamic therapy (PDT) has been known for over a hundred years, but …

A successful cure of cancer by biopharmaceuticals with intracellular targets is dependent on
both specific and sufficient delivery of the drug to the cytosol or nuclei of malignant cells …

A photosensitizer is defined as a chemical entity, which upon absorption of light induces a
chemical or physical alteration of another chemical entity. Some photosensitizers are utilized …

▪ Abstract Ribosome-inactivating proteins (RIPs) are toxic N-glycosidases that depurinate
the universally conserved α-sarcin loop of large rRNAs. This depurination inactivates the …

Coupling anticancer drugs to synthetic polymers is a promising approach to improve the
efficacy and reduce the side effects of these drugs. The pH-activated polymer has been …

A number of protein toxins of bacterial and plant origin have cytosolic targets, and
knowledge about these toxins have provided us with essential information about …

Polymer vesicles formed by a pair of oppositely charged poly (ethylene glycol)(PEG)-based
block aniomer and homocatiomer, termed “PICsomes”, have tunable size, and are …

This article reviews a novel technology, named photochemical internalisation (PCI), for light-
induced delivery of genes, proteins and many other classes of therapeutic molecules …

Background Photochemical internalisation, a novel minimally invasive treatment, has shown
promising preclinical results in enhancing and site-directing the effect of anticancer drugs by …