Tryptophan biochemistry: structural, nutritional, metabolic, and medical aspects in humans

L Palego, L Betti, A Rossi… - Journal of amino …, 2016 - Wiley Online Library
L‐Tryptophan is the unique protein amino acid (AA) bearing an indole ring: its
biotransformation in living organisms contributes either to keeping this chemical group in …

Rationally designed peptides and peptidomimetics as inhibitors of amyloid-β (Aβ) aggregation: Potential therapeutics of Alzheimer's disease

D Goyal, S Shuaib, S Mann, B Goyal - ACS combinatorial science, 2017 - ACS Publications
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The worldwide effort to develop peptide …

Benzofuran and indole: promising scaffolds for drug development in Alzheimer's disease

D Goyal, A Kaur, B Goyal - ChemMedChem, 2018 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The Food and Drug Administration has …

Peptide‐based molecular strategies to interfere with protein misfolding, aggregation, and cell degeneration

V Armiento, A Spanopoulou… - Angewandte Chemie …, 2020 - Wiley Online Library
Protein misfolding into amyloid fibrils is linked to more than 40 as yet incurable cell‐and
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and type 2 …

[HTML][HTML] Peptide based therapeutics and their use for the treatment of neurodegenerative and other diseases

MH Baig, K Ahmad, M Saeed, AM Alharbi… - Biomedicine & …, 2018 - Elsevier
Bioactive peptides are actively involved in different biological functions and importantly
contribute to human health, and the use of peptides as therapeutics has a long successful …

Design of LVFFARK and LVFFARK-functionalized nanoparticles for inhibiting amyloid β-protein fibrillation and cytotoxicity

N Xiong, XY Dong, J Zheng, FF Liu… - ACS applied materials & …, 2015 - ACS Publications
Aggregation of amyloid β-protein (Aβ) into amyloid oligomers and fibrils is pathologically
linked to Alzheimer's disease (AD). Hence, the inhibition of Aβ aggregation is essential for …

Natural tripeptide-based inhibitor of multifaceted amyloid β toxicity

K Rajasekhar, C Madhu… - ACS chemical …, 2016 - ACS Publications
Accumulation of amyloid beta (Aβ) peptide and its aggregates in the human brain is
considered as one of the hallmarks of Alzheimer's disease (AD). The polymorphic oligomers …

Tau aggregation inhibiting peptides as potential therapeutics for Alzheimer disease

I Aillaud, SA Funke - Cellular and Molecular Neurobiology, 2023 - Springer
Alzheimer disease (AD) is the most common progressive neurodegenerative disorder. AD
causes enormous personal and economic burden to society as currently only limited …

Insights into the pathophysiology of Alzheimer's disease and potential therapeutic targets: A current perspective

K Rajah Kumaran, S Yunusa, E Perimal… - Journal of …, 2023 - content.iospress.com
The aging population increases steadily because of a healthy lifestyle and medical
advancements in healthcare. However, Alzheimer's disease (AD) is becoming more …

Aβ and Tau Interact with Metal Ions, Lipid Membranes and Peptide-Based Amyloid Inhibitors: Are These Common Features Relevant in Alzheimer's Disease?

G Di Natale, G Sabatino, MFM Sciacca, R Tosto… - Molecules, 2022 - mdpi.com
In the last two decades, the amyloid hypothesis, ie, the abnormal accumulation of toxic Aβ
assemblies in the brain, has been considered the mainstream concept sustaining research …