New insights into the development of the human cerebral cortex

Z Molnár, GJ Clowry, N Šestan, A Alzu'bi… - Journal of …, 2019 - Wiley Online Library
The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …

Development and evolution of thalamocortical connectivity

Z Molnár, KY Kwan - Cold Spring Harbor Perspectives in …, 2024 - cshperspectives.cshlp.org
Conscious perception in mammals depends on precise circuit connectivity between cerebral
cortex and thalamus; the evolution and development of these structures are closely linked …

Emerging roles of long non-coding RNAs as drivers of brain evolution

G Zimmer-Bensch - Cells, 2019 - mdpi.com
Mammalian genomes encode tens of thousands of long-noncoding RNAs (lncRNAs), which
are capable of interactions with DNA, RNA and protein molecules, thereby enabling a …

Untangling cortical complexity during development

T Mukhtar, V Taylor - Journal of experimental neuroscience, 2018 - journals.sagepub.com
The cerebral cortex is composed of billions of morphologically and functionally distinct
neurons. These neurons are produced and organized in a regimental fashion during …

Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF

H Sato, J Hatakeyama, T Iwasato, K Araki… - Elife, 2022 - elifesciences.org
Neuronal abundance and thickness of each cortical layer are specific to each area, but how
this fundamental feature arises during development remains poorly understood. While some …

Morphological and functional aspects of progenitors perturbed in cortical malformations

S Bizzotto, F Francis - Frontiers in cellular neuroscience, 2015 - frontiersin.org
In this review, we discuss molecular and cellular mechanisms important for the function of
neuronal progenitors during development, revealed by their perturbation in different cortical …

EphrinA5 regulates cell motility by modulating Snhg15/DNA triplex-dependent targeting of DNMT1 to the Ncam1 promoter

CB Yildiz, T Kundu, J Gehrmann, J Koesling… - Epigenetics & …, 2023 - Springer
Cell–cell communication is mediated by membrane receptors and their ligands, such as the
Eph/ephrin system, orchestrating cell migration during development and in diverse cancer …

Methods for single-cell isolation and preparation

D Pensold, G Zimmer-Bensch - Single-cell Sequencing and Methylation …, 2020 - Springer
Within the last decade, single-cell analysis has revolutionized our understanding of cellular
processes and heterogeneity across all disciplines of life science. As the transcriptome …

Coupling progenitor and neuronal diversity in the developing neocortex

S Govindan, D Jabaudon - FEBS letters, 2017 - Wiley Online Library
The adult neocortex is composed of several types of glutamatergic neurons, which are
sequentially born from progenitors during development. The extent and nature of progenitor …

Decreased maternal behavior and anxiety in ephrin‐A5−/− mice

M Sheleg, Q Yu, C Go, GC Wagner… - Genes, Brain and …, 2017 - Wiley Online Library
During development of the nervous system, molecular signals mediating cell–cell
interactions play critical roles in the guidance of axonal growth and establishment of …