International harmonization in performing and reporting minimal residual disease assessment in multiple myeloma trials

LJ Costa, BA Derman, S Bal, S Sidana, S Chhabra… - Leukemia, 2021 - nature.com
Minimal residual disease (MRD) assessment is incorporated in an increasing number of
multiple myeloma (MM) clinical trials as a correlative analysis, an endpoint or even as a …

Emerging immunotherapies in multiple myeloma

UA Shah, S Mailankody - Bmj, 2020 - bmj.com
Despite considerable advances in treatment approaches in the past two decades, multiple
myeloma remains an incurable disease. Treatments for myeloma continue to evolve with …

Carfilzomib, lenalidomide, and dexamethasone plus transplant in newly diagnosed multiple myeloma

JK Jasielec, T Kubicki, N Raje, R Vij… - Blood, The Journal …, 2020 - ashpublications.org
In this phase 2 multicenter study, we evaluated the incorporation of autologous stem cell
transplantation (ASCT) into a carfilzomib-lenalidomide-dexamethasone (KRd) regimen for …

Daratumumab for the management of newly diagnosed and relapsed/refractory multiple myeloma: current and emerging treatments

M Offidani, L Corvatta, S Morè, D Nappi… - Frontiers in …, 2021 - frontiersin.org
Immunotherapy is changing the paradigm of multiple myeloma (MM) management and
daratumumab is the first-in-class human monoclonal antibody targeting CD38 approved for …

How to Treat High-Risk Myeloma at Diagnosis and Relapse.

J Caro, S Al Hadidi, S Usmani, AJ Yee… - American Society of …, 2021 - europepmc.org
Survival in multiple myeloma has improved greatly during the past 2 decades, but this
change has primarily benefited patients who have standard-risk disease. Patients with high …

Second malignancies in multiple myeloma; emerging patterns and future directions

K Maclachlan, B Diamond, F Maura… - Best Practice & …, 2020 - Elsevier
The changing landscape of treatment options for multiple myeloma has led to a higher
proportion of patients achieving deep, long-lasting responses to therapy. With the …

Minimal residual disease assessment in multiple myeloma patients: minimal disease with maximal implications

C Charalampous, T Kourelis - Frontiers in Oncology, 2022 - frontiersin.org
Multiple Myeloma (MM), the second most common hematologic malignancy, has been the
target of many therapeutic advances over the past two decades. The introduction of novel …

Defining the undetectable: the current landscape of minimal residual disease assessment in multiple myeloma and goals for future clarity

BT Diamond, E Rustad, K Maclachlan, K Thoren, C Ho… - Blood reviews, 2021 - Elsevier
Multiple Myeloma, the second most prevalent hematologic malignancy, yet lacks an
established curative therapy. However, overall response rate to modern four-drug regimens …

The role of high‐dose melphalan with autologous stem‐cell transplant in multiple myeloma: is it time for a paradigm shift?

D Kazandjian, CC Mo, O Landgren… - British journal of …, 2020 - Wiley Online Library
Recent advances in multiple myeloma include numerous approvals of novel therapies with
unprecedented efficacy, a rapid and sustained tempo of new drug development, and further …

Minimal residual disease in multiple myeloma: state of the art and future perspectives

R Mina, S Oliva, M Boccadoro - Journal of clinical medicine, 2020 - mdpi.com
Minimal residual disease (MRD) detection represents a sensitive tool to appropriately
measure the response obtained with therapies for multiple myeloma (MM). The achievement …