Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance
Acute inflammatory lesions of the placenta consist of diffuse infiltration of neutrophils at
different sites in the organ. These lesions include acute chorioamnionitis, funisitis, and …
different sites in the organ. These lesions include acute chorioamnionitis, funisitis, and …
The use of high‐dimensional biology (genomics, transcriptomics, proteomics, and metabolomics) to understand the preterm parturition syndrome
High‐dimensional biology (HDB) refers to the simultaneous study of the genetic variants
(DNA variation), transcription (messenger RNA [mRNA]), peptides and proteins, and …
(DNA variation), transcription (messenger RNA [mRNA]), peptides and proteins, and …
Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes
Background Intra-amniotic infection is present in 10% of patients with an episode of preterm
labor, and is a risk factor for impending preterm delivery and neonatal morbidity/mortality …
labor, and is a risk factor for impending preterm delivery and neonatal morbidity/mortality …
Sterile intra-amniotic inflammation in asymptomatic patients with a sonographic short cervix: prevalence and clinical significance
Objective: To determine the frequency and clinical significance of sterile and microbial-
associated intra-amniotic inflammation in asymptomatic patients with a sonographic short …
associated intra-amniotic inflammation in asymptomatic patients with a sonographic short …
Evidence of perturbations of the cytokine network in preterm labor
Objective Intraamniotic inflammation/infection is the only mechanism of disease with
persuasive evidence of causality for spontaneous preterm labor/delivery. Previous studies …
persuasive evidence of causality for spontaneous preterm labor/delivery. Previous studies …
A rapid interleukin-6 bedside test for the identification of intra-amniotic inflammation in preterm labor with intact membranes
P Chaemsaithong, R Romero… - The Journal of …, 2016 - Taylor & Francis
Objective: Preterm birth is associated with 5–18% of pregnancies and is the leading cause
of neonatal morbidity and mortality. Amniotic fluid (AF) interleukin-6 (IL-6) is a key cytokine …
of neonatal morbidity and mortality. Amniotic fluid (AF) interleukin-6 (IL-6) is a key cytokine …
Midtrimester amniotic fluid concentrations of interleukin-6 and interferon-gamma-inducible protein-10: evidence for heterogeneity of intra-amniotic inflammation and …
MT Gervasi, R Romero, G Bracalente… - Journal of perinatal …, 2012 - degruyter.com
Introduction: Intra-amniotic inflammation is traditionally defined as an elevation of amniotic
fluid interleukin (IL)-6. Previous case control studies have suggested an association …
fluid interleukin (IL)-6. Previous case control studies have suggested an association …
Twenty-four percent of patients with clinical chorioamnionitis in preterm gestations have no evidence of either culture-proven intraamniotic infection or intraamniotic …
Background Recent studies on clinical chorioamnionitis at term suggest that some patients
with this diagnosis have neither intraamniotic infection nor intraamniotic inflammation. A …
with this diagnosis have neither intraamniotic infection nor intraamniotic inflammation. A …
A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in …
JH Lee, R Romero, SM Kim… - The Journal of …, 2016 - Taylor & Francis
Objective: Antibiotic administration is a standard practice in preterm premature rupture of
membranes (PROM). Specific anti-microbial agents often include ampicillin and/or …
membranes (PROM). Specific anti-microbial agents often include ampicillin and/or …
Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery
R Romero, S Mazaki-Tovi, E Vaisbuch… - The journal of …, 2010 - Taylor & Francis
Objective. Biomarkers for preterm labor (PTL) and delivery can be discovered through the
analysis of the transcriptome (transcriptomics) and protein composition (proteomics) …
analysis of the transcriptome (transcriptomics) and protein composition (proteomics) …