The precise patterns of neuronal assembly during development determine all functional
outputs of a nervous system; these may range from simple reflexes to learning, memory …

Autism spectrum disorder (ASD) is comprised of several conditions characterized by
alterations in social interaction, communication, and repetitive behaviors. Genetic and …

SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of
protein complexes through physical interactions with a pool of proline-rich/noncanonical …

Information derived from experiences is incorporated into the brain as changes to
ensembles of cells, termed engram cells, which allow memory storage and recall. The …

During development, pyramidal neurons undergo dynamic regulation of AMPA receptor
(AMPAR) subunit composition and density to help drive synaptic plasticity and maturation …

The SHANK family of proteins play critical structural and functional roles in the postsynaptic
density (PSD) at excitatory glutamatergic synapses. Through their multidomain structure they …

The SHANK scaffolding proteins are important organizers for signaling proteins in the
postsynapse of excitatory neurons. The functional significance of SHANK proteins becomes …

NMDA-type glutamate receptors are critical for synaptic plasticity in the central nervous
system. Their unique properties and age-dependent arrangement of subunit types underpin …

Autism spectrum disorder (ASD) is a disruptive neurodevelopmental disorder manifested by
abnormal social interactions, communication, emotional circuits, and repetitive behaviors …

SH3 and multiple ankyrin repeat domains 1 (SHANK1) is a scaffold protein, plays an
important role in the normal function of neuron system. It has recently been shown to be a …