Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …

The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

Background Hepatocellular carcinoma (HCC) is one of the most common malignancies
worldwide, and tumor recurrence and metastasis are major factors that contribute to the poor …

The emergence of a nucleosome-based chromatin structure accompanied the evolutionary
transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the …

In eukaryotic cells, DNA replication proceeds with continuous synthesis of leading-strand
DNA and discontinuous synthesis of lagging-strand DNA. Here we describe a method …

DNA replication-coupled (RC) nucleosome assembly is mediated by histone chaperones
and is fundamental for epigenetic inheritance and maintenance of genomic integrity. The …

During S phase, replicated DNA must be assembled into nucleosomes using both newly
synthesized and parental histones in a process that is tightly coupled to DNA replication …