Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche
SC Schüler, Y Liu, S Dumontier… - Frontiers in Cell and …, 2022 - frontiersin.org
The extracellular matrix (ECM) is an interconnected macromolecular scaffold occupying the
space between cells. Amongst other functions, the ECM provides structural support to …
space between cells. Amongst other functions, the ECM provides structural support to …
Basement membrane collagens and disease mechanisms
Basement membranes (BMs) are specialised extracellular matrix (ECM) structures and
collagens are a key component required for BM function. While collagen IV is the major BM …
collagens are a key component required for BM function. While collagen IV is the major BM …
Hic1 defines quiescent mesenchymal progenitor subpopulations with distinct functions and fates in skeletal muscle regeneration
Many adult tissues contain resident stem cells, such as the Pax7+ satellite cells within
skeletal muscle, that regenerate parenchymal elements following damage. Tissue-resident …
skeletal muscle, that regenerate parenchymal elements following damage. Tissue-resident …
The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy
Decline in skeletal muscle cell size (myofiber atrophy) is a key feature of cancer-induced
wasting (cachexia). In particular, atrophy of the diaphragm, the major muscle responsible for …
wasting (cachexia). In particular, atrophy of the diaphragm, the major muscle responsible for …
Systematic review of cerebral phenotypes associated with monogenic cerebral small‐vessel disease
E Whittaker, S Thrippleton, LYW Chong… - Journal of the …, 2022 - Am Heart Assoc
Background Cerebral small‐vessel disease (cSVD) is an important cause of stroke and
vascular dementia. Most cases are multifactorial, but an emerging minority have a …
vascular dementia. Most cases are multifactorial, but an emerging minority have a …
Weighted gene co-expression network analysis identifies molecular pathways and hub genes involved in broiler White Striping and Wooden Breast myopathies
In recent years, the poultry industry has experienced an increased incidence of myopathies
affecting breasts of fast-growing broilers, such as White Striping (WS) and Wooden Breast …
affecting breasts of fast-growing broilers, such as White Striping (WS) and Wooden Breast …
Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome
Gould syndrome is a rare multisystem disorder resulting from autosomal dominant mutations
in the collagen-encoding genes COL4A1 and COL4A2. Human patients and Col4a1 mutant …
in the collagen-encoding genes COL4A1 and COL4A2. Human patients and Col4a1 mutant …
Elevated TGFβ signaling contributes to cerebral small vessel disease in mouse models of Gould syndrome
K Branyan, C Labelle-Dumais, X Wang, G Hayashi… - Matrix Biology, 2023 - Elsevier
Cerebral small vessel disease (CSVD) is a leading cause of stroke and vascular cognitive
impairment and dementia. Studying monogenic CSVD can reveal pathways that are …
impairment and dementia. Studying monogenic CSVD can reveal pathways that are …
PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease
Neurovascular coupling (NVC), a vital physiological process that rapidly and precisely
directs localized blood flow to the most active regions of the brain, is accomplished in part by …
directs localized blood flow to the most active regions of the brain, is accomplished in part by …
COL4A1 as a novel oncogene associated with the clinical characteristics of malignancy predicts poor prognosis in glioma
H Wang, Z Liu, A Li, J Wang, J Liu… - Experimental and …, 2021 - spandidos-publications.com
Studies have indicated that collagen α‑1 (IV) chain (COL4A1) has an indispensable
regulatory role in the complex pathological mechanisms of numerous types of malignant …
regulatory role in the complex pathological mechanisms of numerous types of malignant …