Clinical significance and pathogenesis of staphylococcal small colony variants in persistent infections

BC Kahl, K Becker, B Löffler - Clinical microbiology reviews, 2016 - Am Soc Microbiol
Small colony variants (SCVs) were first described more than 100 years ago for
Staphylococcus aureus and various coagulase-negative staphylococci. Two decades ago …

Biomaterials approaches to treating implant-associated osteomyelitis

JA Inzana, EM Schwarz, SL Kates, HA Awad - Biomaterials, 2016 - Elsevier
Orthopaedic devices are the most common surgical devices associated with implant-related
infections and Staphylococcus aureus (S. aureus) is the most common causative pathogen …

Synthesis, biological and environmental applications of hydroxyapatite and its composites with organic and inorganic coatings

T Varadavenkatesan, R Vinayagam, S Pai… - Progress in Organic …, 2021 - Elsevier
The need for biomaterials is in ever-increasing demand for a plethora of applications
nowadays. Hydroxyapatite (HAP) is a primary constituent of bones and teeth in vertebrates …

Antibiotic-loaded biomaterials and the risks for the spread of antibiotic resistance following their prophylactic and therapeutic clinical use

D Campoccia, L Montanaro, P Speziale, CR Arciola - Biomaterials, 2010 - Elsevier
Antibiotic-loaded biomaterials are currently part of standard medical procedures for both
local treatment and prevention of implant infections. The achievement of local delivery of …

Design of calcium phosphate ceramics for drug delivery applications in bone diseases: A review of the parameters affecting the loading and release of the therapeutic …

M Parent, H Baradari, E Champion, C Damia… - Journal of Controlled …, 2017 - Elsevier
Effective treatment of critical-size defects is a key challenge in restorative surgery of bone.
The strategy covers the implantation of biocompatible, osteoconductive, bioactive and …

Antibacterial nanosized silver substituted hydroxyapatite: synthesis and characterization

N Rameshbabu, TS Sampath Kumar… - … Research Part A, 2007 - Wiley Online Library
Abstract The silver (0.5–3 at%) substituted nanosize hydroxyapatites (AgHAs) were
synthesized by microwave processing. The X‐ray diffraction (XRD) peaks are very broad …

Synthetic hydroxyapatite in pharmaceutical applications

J Kolmas, S Krukowski, A Laskus, M Jurkitewicz - Ceramics International, 2016 - Elsevier
Synthetic hydroxyapatite plays a key role in implantology, stomatology, and regenerative
medicine. Thanks to its non-toxicity and biocompatibility with bone and mineralised dental …

Understanding osteomyelitis and its treatment through local drug delivery system

SK Nandi, S Bandyopadhyay, P Das, I Samanta… - Biotechnology …, 2016 - Elsevier
Chronic osteomyelitis is a major challenge in bone surgery. Conventional use of antibiotics
is not an effective way to control the malaise due to so many reasons. Determination of …

An antibacterial coated polymer prevents biofilm formation and implant-associated infection

H Ishihama, K Ishii, S Nagai, H Kakinuma, A Sasaki… - Scientific reports, 2021 - nature.com
To prevent infections associated with medical implants, various antimicrobial silver-coated
implant materials have been developed. However, these materials do not always provide …

Local antibiotic delivery systems for the treatment of osteomyelitis–A review

SK Nandi, P Mukherjee, S Roy, B Kundu, DK De… - Materials Science and …, 2009 - Elsevier
Osteomyelitis, an inflammatory process accompanied by bone destruction, is caused by
infective microorganisms. The high success rates of antimicrobial therapy by conventional …