Myocardial ischemia‑reperfusion injury (MIRI) is a severe injury to the ischemic myocardium
following the recovery of blood flow. Currently, there is no effective treatment for MIRI in …

Tumors often show, compared to normal tissues, a markedly decreased extracellular pH
resulting from anaerobic or aerobic glycolysis in combination with a reduced removal of …

In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

Background Gastric cancer (GC) is one of the deadliest malignant tumors with unknown
pathogenesis. Due to its treatment resistance, high recurrence rate, and lack of reliable early …

Knee osteoarthritis (KOA) is the most common form of joint degeneration with increasing
prevalence and incidence in recent decades. KOA is a molecular disorder characterized by …

Endothelial cells play critical roles in circulatory homeostasis and are also the gateway to
the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells …

Background The identification of novel targets for recovering sorafenib resistance is pivotal
for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed degradation of …

MicroRNAs (miRNAs) are, small (roughly 19–25 nucleotides in length), conserved, non-
coding, single-stranded, and functional RNA molecules with the properties of gene …

Imbalanced regulation of reactive oxygen species (ROS) and antioxidant factors in cells is
known as “oxidative stress (OS)”. OS regulates key cellular physiological responses through …

Osteoarthritis (OA) is a degenerative whole joint disease, for which no preventative or
therapeutic biological interventions are available. This is likely due to the fact that OA …