The interplay of signaling pathways with miRNAs in cholangiocarcinoma pathogenicity and targeted therapy
Cholangiocarcinoma (CCA), the second most frequent liver cancer after hepatocellular
carcinoma, has been rising worldwide in recent epidemiological research. This neoplasia's …
carcinoma, has been rising worldwide in recent epidemiological research. This neoplasia's …
Pathogenesis, diagnosis, and management of cholangiocarcinoma
Cholangiocarcinomas (CCAs) are hepatobiliary cancers with features of cholangiocyte
differentiation; they can be classified anatomically as intrahepatic CCA (iCCA), perihilar …
differentiation; they can be classified anatomically as intrahepatic CCA (iCCA), perihilar …
Multifaceted roles of GSK‐3 in cancer and autophagy‐related diseases
R Mancinelli, G Carpino, S Petrungaro… - Oxidative medicine …, 2017 - Wiley Online Library
GSK‐3 is a ubiquitously expressed serine/threonine kinase existing as GSK‐3α and GSK‐
3β isoforms, both active under basal conditions and inactivated upon phosphorylation by …
3β isoforms, both active under basal conditions and inactivated upon phosphorylation by …
[PDF][PDF] Lysyl oxidase‐like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma
CCL Wong, APW Tse, YP Huang, YT Zhu… - …, 2014 - Wiley Online Library
Poor prognosis of cancers, including hepatocellular carcinoma (HCC), is mainly associated
with metastasis; however, the underlying mechanisms remain poorly understood. This article …
with metastasis; however, the underlying mechanisms remain poorly understood. This article …
[PDF][PDF] MicroRNA‐26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin‐6‐Stat3 pathway
X Yang, L Liang, XF Zhang, HL Jia, Y Qin, XC Zhu… - …, 2013 - Wiley Online Library
Down‐regulation of microRNA‐26a (miR‐26a) is associated with poor prognosis of
hepatocellular carcinoma (HCC), but its functional mechanism in HCC remains unclear. In …
hepatocellular carcinoma (HCC), but its functional mechanism in HCC remains unclear. In …
MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis
G Koukos, C Polytarchou, JL Kaplan… - Gastroenterology, 2013 - Elsevier
Background & Aims Altered levels and functions of microRNAs (miRs) have been associated
with inflammatory bowel diseases (IBDs), although little is known about their roles in …
with inflammatory bowel diseases (IBDs), although little is known about their roles in …
MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine
Y Xiang, N Ma, D Wang, Y Zhang, J Zhou, G Wu… - Oncogene, 2014 - nature.com
Epithelial ovarian cancer (EOC) is a highly lethal gynaecological malignancy. Cisplatin is
the basal chemotherapeutic agent used to treat EOC, but resistance to cisplatin leads to …
the basal chemotherapeutic agent used to treat EOC, but resistance to cisplatin leads to …
Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance
DF Calvisi, L Boulter, J Vaquero… - Nature Reviews …, 2023 - nature.com
Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary
tree. CCA has a poor prognosis, its clinical management remains challenging, and effective …
tree. CCA has a poor prognosis, its clinical management remains challenging, and effective …
[PDF][PDF] MicroRNA‐26a suppresses angiogenesis in human hepatocellular carcinoma by targeting hepatocyte growth factor‐cMet pathway
X Yang, XF Zhang, X Lu, HL Jia, L Liang, QZ Dong… - …, 2014 - Wiley Online Library
MicroRNA (miR)‐26a can suppress tumor growth and metastasis of hepatocellular
carcinoma (HCC). Since angiogenesis is important for tumor growth and metastasis, we …
carcinoma (HCC). Since angiogenesis is important for tumor growth and metastasis, we …
[HTML][HTML] The crosstalk between microRNAs and the Wnt/β-catenin signaling pathway in cancer
Y Peng, X Zhang, X Feng, X Fan, Z Jin - Oncotarget, 2017 - ncbi.nlm.nih.gov
Mounting evidence has indicated microRNA (miR) dysregulation and the Wnt/β-catenin
signaling pathway jointly drive carcinogenesis, cancer metastasis, and drug-resistance. The …
signaling pathway jointly drive carcinogenesis, cancer metastasis, and drug-resistance. The …