Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

Cell death supports morphogenesis during development and homeostasis after birth by
removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating …

The tumour suppressor gene TP53 is mutated in~ 50% of human cancers. In addition to its
function in tumour suppression, p53 also plays a major role in the response of malignant as …

Active cell death, in its many forms, is a fundamental biological process. Studies over the
past several decades have explored the functions and consequences of cellular demise and …

The ability of a cell to undergo mitochondrial apoptosis is governed by pro-and anti-
apoptotic members of the BCL-2 protein family. The equilibrium of pro-versus anti-apoptotic …

Apoptotic cell death is widely considered a positive process that both prevents and treats
cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also …

During apoptosis, the mitochondrial outer membrane is permeabilized, leading to the
release of cytochrome c that activates downstream caspases. Mitochondrial outer …

Reactive oxygen species (ROS) play an important role in determining the fate of normal
stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self …

Cell death is part of the lifecycle of every multicellular organism. Nineteenth-century
pathologists already recognised that organised forms of cell death must exist to explain the …