Lactic acid bacteria (LAB) are important starter, commensal, or pathogenic microorganisms.
The stress physiology of LAB has been studied in depth for over 2 decades, fueled mostly by …

Like for all microbes, the goal of every pathogen is to survive and replicate. However, to
overcome the formidable defenses of their hosts, pathogens are also endowed with traits …

Many bacterial species are represented by a pan-genome, whose genetic repertoire far
outstrips that of any single bacterial genome. Here we investigate how a bacterial pan …

The stringent response is initiated by rapid (p) ppGpp synthesis, which leads to a profound
reprogramming of gene expression in most bacteria. The stringent phenotype seems to be …

The stringent response is a conserved global regulatory mechanism that is related to the
synthesis of (p) ppGpp nucleotides. Gram-positive bacteria, such as Staphylococcus aureus …

In nearly all bacterial species examined so far, amino acid starvation triggers the rapid
accumulation of the nucleotide second messenger (p) ppGpp, the effector of the stringent …

High levels of copper are toxic and therefore bacteria must limit free intracellular levels to
prevent cellular damage. In this study, we show that a number of pneumococcal genes are …

In most bacteria, nutrient limitations provoke the stringent control through the rapid synthesis
of the alarmones pppGpp and ppGpp. Little is known about the stringent control in the …

Streptococcus pneumoniae is a commensal bacterium and invasive pathogen that causes
millions of deaths worldwide. The pneumococcal vaccine offers limited protection, and the …

In the mammalian gut, bacteria compete for resources to maintain their populations, but the
factors determining their success are poorly understood. We report that the human gut …