Soil-transmitted helminths affect approximately 1.5 billion people worldwide. However, as no
vaccine is currently available for humans, the current strategy for elimination as a public …

Soil-transmitted helminths (STH) affect hundreds of millions worldwide and are some of the
most important neglected tropical diseases in terms of morbidity. Due to the difficulty in …

The impact of the host immune environment on parasite transcription and fitness is currently
unknown. It is widely held that hookworm infections have an immunomodulatory impact on …

Parasitic nematodes of humans, animals and plants have a major, adverse impact on global
health and agricultural production worldwide. To cope with their surrounding environment in …

Parasitic roundworms (nematodes) have lost genes involved in the de novo biosynthesis of
haem, but have evolved the capacity to acquire and utilise exogenous haem from host …

The ability of helminths to manipulate the immune system of their hosts to ensure their own
survival is often credited with affecting responses to other pathogens. We undertook co …

Abstract Background The human hookworm, Necator americanus, is a parasite that infects
almost half a billion people worldwide. Although treatment is available, vaccination is …

Approximately 0.4 billion individuals worldwide are infected with hookworm. An effective
vaccine is needed to not only improve the health of those affected and at high risk, but also …

Resistin-like molecule α (RELMα) is a highly secreted protein in type 2 (Th2) cytokine-
induced inflammation including helminth infection and allergy. In infection with …

Animal-parasitic nematodes have thus far been largely refractory to genetic manipulation,
and methods employed to effect RNA interference (RNAi) have been ineffective or …