REV-ERB and ROR nuclear receptors as drug targets
DJ Kojetin, TP Burris - Nature reviews Drug discovery, 2014 - nature.com
The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …
The cerebellar involvement in autism spectrum disorders: from the social brain to mouse models
Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that include
a variety of forms and clinical phenotypes. This heterogeneity complicates the clinical and …
a variety of forms and clinical phenotypes. This heterogeneity complicates the clinical and …
Molecular components of the mammalian circadian clock
CH Ko, JS Takahashi - Human molecular genetics, 2006 - academic.oup.com
Circadian rhythms are∼ 24-h oscillations in behavior and physiology, which are internally
generated and function to anticipate the environmental changes associated with the solar …
generated and function to anticipate the environmental changes associated with the solar …
[图书][B] What's wrong with my mouse?: behavioral phenotyping of transgenic and knockout mice
JN Crawley - 2007 - books.google.com
Dr. Jacqueline N. Crawley, author of the First and Second Editions of What's Wrong with My
Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field calls …
Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field calls …
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism
AM Jetten - Nuclear receptor signaling, 2009 - journals.sagepub.com
The last few years have witnessed a rapid increase in our knowledge of the retinoid-related
orphan receptors RORα,-β, and-γ (NR1F1-3), their mechanism of action, physiological …
orphan receptors RORα,-β, and-γ (NR1F1-3), their mechanism of action, physiological …
International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …
gene network programs involved in a wide range of physiologic processes. This review will …
Orphan nuclear receptors: from gene to function
V Giguère - Endocrine reviews, 1999 - academic.oup.com
II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of
action III. Orphan Nuclear Receptors A. Definition
action III. Orphan Nuclear Receptors A. Definition
[HTML][HTML] RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy-and 20, 23-dihydroxyvitamin D
AT Slominski, TK Kim, Y Takeda, Z Janjetovic… - The FASEB …, 2014 - ncbi.nlm.nih.gov
RORα and RORγ are expressed in human skin cells that produce the noncalcemic 20-
hydroxyvitamin D 3 [20 (OH) D 3] and 20, 23-dihydroxyvitamin D 3 [20, 23 (OH) 2 D 3] …
hydroxyvitamin D 3 [20 (OH) D 3] and 20, 23-dihydroxyvitamin D 3 [20, 23 (OH) 2 D 3] …
Ca2+/CaM-Dependent Kinases: From Activation to Function
SS Hook, AR Means - Annual review of pharmacology and …, 2001 - annualreviews.org
Calmodulin (CaM) is an essential protein that serves as a ubiquitous intracellular receptor
for Ca2+. The Ca2+/CaM complex initiates a plethora of signaling cascades that culminate …
for Ca2+. The Ca2+/CaM complex initiates a plethora of signaling cascades that culminate …
Redundant function of REV-ERBα and β and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms
The mammalian circadian clockwork is composed of a core PER/CRY feedback loop and
additional interlocking loops. In particular, the ROR/REV/Bmal1 loop, consisting of ROR …
additional interlocking loops. In particular, the ROR/REV/Bmal1 loop, consisting of ROR …