[HTML][HTML] AID function in somatic hypermutation and class switch recombination: AID function in somatic hypermutation and class switch recombination
K Yu - Acta biochimica et biophysica Sinica, 2022 - ncbi.nlm.nih.gov
Activation-induced cytidine deaminase (AID) initiates somatic hypermutation of
immunoglobulin (Ig) gene variable regions and class switch recombination (CSR) of Ig …
immunoglobulin (Ig) gene variable regions and class switch recombination (CSR) of Ig …
A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency
IRF4 International Consortium, O Fornes, A Jia… - Science …, 2023 - science.org
Interferon regulatory factor 4 (IRF4) is a transcription factor (TF) and key regulator of immune
cell development and function. We report a recurrent heterozygous mutation in IRF4, p …
cell development and function. We report a recurrent heterozygous mutation in IRF4, p …
LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway
Y Wang, J Liu, C Akatsu, R Zhang… - Proceedings of the …, 2022 - National Acad Sciences
Elimination of autoreactive developing B cells is an important mechanism to prevent
autoantibody production. However, how B cell receptor (BCR) signaling triggers apoptosis of …
autoantibody production. However, how B cell receptor (BCR) signaling triggers apoptosis of …
MZB1 promotes the secretion of J-chain–containing dimeric IgA and is critical for the suppression of gut inflammation
E Xiong, Y Li, Q Min, C Cui, J Liu… - Proceedings of the …, 2019 - National Acad Sciences
IgA is the most abundantly produced antibody in the body and plays a crucial role in gut
homeostasis and mucosal immunity. IgA forms a dimer that covalently associates with the …
homeostasis and mucosal immunity. IgA forms a dimer that covalently associates with the …
Essential role of NADPH oxidase–dependent production of reactive oxygen species in maintenance of sustained B cell receptor signaling and B cell proliferation
YY Feng, M Tang, M Suzuki, C Gunasekara… - The Journal of …, 2019 - journals.aai.org
Reactive oxygen species (ROS) are not only toxic substances inducing oxidative stress but
also play a role as a second messenger in signal transduction through various receptors …
also play a role as a second messenger in signal transduction through various receptors …
Regulation of humoral immune response by HIF-1α-dependent metabolic reprogramming of the germinal center reaction
L Li, C Feng, J Qin, D Li, M Liu, S Han, B Zheng - Cellular Immunology, 2021 - Elsevier
Abstract Hypoxia-inducible factor-1α (HIF-1α) has been implicated in the regulation of many
genes responsible for aerobic glycolysis; however, the role of HIF-1α in B-cell metabolism …
genes responsible for aerobic glycolysis; however, the role of HIF-1α in B-cell metabolism …
Single-cell atlas of splenocytes reveals a critical role of a novel plasma cell‒specific marker Hspa13 in antibody class-switching recombination and somatic …
B Zhai, X Liu, Y Xu, G Zhu, S Zhou, Y He, X Wang… - Molecular …, 2022 - Elsevier
Our previous study had shown that member 13 (Hspa13) of heat shock protein family A
(Hsp70) promotes plasma cell (PC) production and antibody secretion. To further explore …
(Hsp70) promotes plasma cell (PC) production and antibody secretion. To further explore …
Somatic Hypermutation
J Ridani, P Barbulescu, A Martin, JM Di Noia - Molecular Biology of B Cells, 2024 - Elsevier
Somatic hypermutation (SHM) is a mechanism to introduce single base pair changes in the
exons of the antibody gene that encode for the antibody variable region. Some of these …
exons of the antibody gene that encode for the antibody variable region. Some of these …
A tetrameric form of CD40 ligand with potent biological activities in both mouse and human primary B cells
N Lai, Q Min, E Xiong, J Liu, L Zhang, S Yasuda… - Molecular …, 2019 - Elsevier
Abstract CD40 ligand (CD40 L) expressed by activated T cells interacts with CD40 on B cells
and triggers B cell survival, proliferation and differentiation. Deficiency in CD40 L or CD40 in …
and triggers B cell survival, proliferation and differentiation. Deficiency in CD40 L or CD40 in …
Exosomes are predominantly loaded with mRNA transcript encoding cytoplasmic proteins and exclude mRNA transcript encoding nuclear proteins
S Haque, SR Vaiselbuh - bioRxiv, 2020 - biorxiv.org
Abstract Exosomes are nanovesicles (∼ 30-150 nm diameters) released via an endocytic
pathway in almost all mammalian cell types. Exosomes are composed of a lipid bilayer …
pathway in almost all mammalian cell types. Exosomes are composed of a lipid bilayer …