Ether lipids, such as plasmalogens, are peroxisome-derived glycerophospholipids in which
the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether …

Peroxisomes are often dismissed as the cellular hoi polloi, relegated to cleaning up reactive
oxygen chemical debris discarded by other organelles. However, their functions extend far …

In the industrialized world, functional foods have become a part of an everyday diet and are
demonstrated to offer potential health benefits beyond the widely accepted nutritional …

Glycerol-based ether lipids including ether phospholipids form a specialized branch of lipids
that in mammals require peroxisomes for their biosynthesis. They are major components of …

Background Peroxisomes are single membrane-bound organelles named for their role in
hydrogen peroxide production and catabolism. However, their cellular functions extend well …

De novo lipogenesis in adipocytes, especially with high fat feeding, is poorly understood.
We demonstrate that an adipocyte lipogenic pathway encompassing fatty acid synthase …

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone-
receptor superfamily. Originally cloned in 1990, PPARs were found to be mediators of …

Chemical and physico-chemical properties as well as physiological functions of major
mammalian ether-linked glycerolipids, including plasmalogens were reviewed. Their …

Nuclear receptors (NRs) are hormone-sensing transcription factors that translate dietary or
endocrine signals into changes in gene expression. Therefore, the adoption of orphan NRs …

Activation of the Wnt/β-catenin signaling pathway occurs in several types of cancers and
thus it is an attractive target for anticancer drug development. To identify compounds that …