Premenopausal women are protected to some extent from cardiovascular and kidney
diseases. Because this protection weakens after menopause, sex hormones are believed to …

The prevalence of left ventricular diastolic dysfunction (LVDD) sharply increases in women
after menopause and may lead to heart failure. While evidence suggests that estrogens …

Cardiovascular disease (CVD) is the leading cause of death globally for men and women.
Premenopausal women have a lower incidence of hypertension and other cardiovascular …

Aims GPR30 is a novel oestrogen receptor expressed in various tissues, including the heart.
We determined the role of GPR30 in the maintenance of left ventricular (LV) structure and …

The relationship between biological sex and aldosterone on blood pressure (BP) is unclear.
We hypothesized that sex would modify the interaction between aldosterone and vascular …

Sex differences in blood pressure are evident in experimental models and human subjects,
yet the mechanisms underlying this disparity remain equivocal. The current study sought to …

Hypertension is the most prevalent cardiovascular disease of the adult population and is
closely associated with serious cardiovascular events. The burden of hypertension with …

We examined the impact of early diabetes on the circulating and kidney renin-angiotensin
system (RAS) in male and female mRen2. Lewis (mRen2) hypertensive rats. Diabetes (DB) …

Previously, we reported that chronic activation of the estrogen receptor GPR30 by its
selective agonist G-1 decreases blood pressure in ovariectomized hypertensive mRen2 …

Background: Male-female differences in the expression of hypertension and in end-organ
damage are evident in both experimental models and human subjects, with males exhibiting …