Neurodegenerative diseases share the fact that they derive from altered proteins that
undergo an unfolding process followed by formation of β-structures and a pathological …

Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …

Several attempts have been made to treat Alzheimer's disease (AD) using anti-amyloid
strategies with disappointing results. It is clear that the “amyloid cascade hypothesis” alone …

Alzheimer's disease (AD) is a chronic neurodegenerative disease, with the characteristics of
neurofibrillary tangle (NFT) and senile plaque (SP) formation. Although great progresses …

Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Inflammatory reactions could be both beneficial and detrimental to the brain, depending on
strengths of their activation in various stages of neurodegeneration. Mild activation of …

Despite the significant public health issue that it poses, only five medical treatments have
been approved for Alzheimer's disease (AD) and these act to control symptoms rather than …

Background: Inflammation is a part of the first line of defense of the body against invasive
pathogens, and plays a crucial role in tissue regeneration and repair. A proper inflammatory …

Frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative
disorders with different pathological signatures, genetic variability and complex disease …

Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most
common cause of dementia. Deposition of amyloid‐β (Aβ) remains a hallmark feature of the …