Adverse outcome pathways: opportunities, limitations and open questions
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …
formalized, transparent and quality-controlled way, mechanistic information to apical …
Drug-Induced Nephrotoxicity: Clinical Impact and Preclinical in Vitro Models
The kidney is a major target for drug-induced toxicity. Drug-induced nephrotoxicity remains a
major problem in the clinical setting, where the use of nephrotoxic drugs is often …
major problem in the clinical setting, where the use of nephrotoxic drugs is often …
Chip-based human liver–intestine and liver–skin co-cultures–A first step toward systemic repeated dose substance testing in vitro
I Maschmeyer, T Hasenberg, A Jaenicke… - European journal of …, 2015 - Elsevier
Systemic repeated dose safety assessment and systemic efficacy evaluation of substances
are currently carried out on laboratory animals and in humans due to the lack of predictive …
are currently carried out on laboratory animals and in humans due to the lack of predictive …
[HTML][HTML] Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress
High content omic techniques in combination with stable human in vitro cell culture systems
have the potential to improve on current pre-clinical safety regimes by providing detailed …
have the potential to improve on current pre-clinical safety regimes by providing detailed …
Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics
Cisplatin is one of the most widely used chemotherapeutic agents for the treatment of solid
tumours. The major dose-limiting factor is nephrotoxicity, in particular in the proximal tubule …
tumours. The major dose-limiting factor is nephrotoxicity, in particular in the proximal tubule …
3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies
D Mueller, L Krämer, E Hoffmann, S Klein, F Noor - Toxicology in Vitro, 2014 - Elsevier
Predictive in vitro models alternative to in vivo animal will have a significant impact in
toxicology. Conventional 2D models do not reflect the complexity of a 3D organ resulting in …
toxicology. Conventional 2D models do not reflect the complexity of a 3D organ resulting in …
Systems toxicology: real world applications and opportunities
Systems Toxicology aims to change the basis of how adverse biological effects of
xenobiotics are characterized from empirical end points to describing modes of action as …
xenobiotics are characterized from empirical end points to describing modes of action as …
An overview of transcriptional regulation in response to toxicological insult
The completion of the human genome project and the subsequent advent of DNA microarray
and high-throughput sequencing technologies have led to a renaissance in molecular …
and high-throughput sequencing technologies have led to a renaissance in molecular …
Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals
W van der Stel, G Carta, J Eakins, S Darici, J Delp… - Archives of …, 2020 - Springer
Evidence is mounting for the central role of mitochondrial dysfunction in several pathologies
including metabolic diseases, accelerated ageing, neurodegenerative diseases and in …
including metabolic diseases, accelerated ageing, neurodegenerative diseases and in …
Canagliflozin mediated dual inhibition of mitochondrial glutamate dehydrogenase and complex I: an off-target adverse effect
Abstract Recent FDA Drug Safety Communications report an increased risk for acute kidney
injury in patients treated with the gliflozin class of sodium/glucose co-transport inhibitors …
injury in patients treated with the gliflozin class of sodium/glucose co-transport inhibitors …