Many common chronic diseases and syndromes are ageing-related. This raises the
prospect that therapeutic agents that target the biological changes of ageing will prevent or …

The current increase in lifespan without an equivalent increase in healthspan poses a grave
challenge to the healthcare system and a severe burden on society. However, some …

Abnormal cognitive ageing, including dementia, poses serious challenges to health and
social systems in ageing populations. As such, characterizing factors associated with …

Reduced activity of insulin/insulin-like growth factor signaling (IIS) extends health and life
span in mammals. Loss of the insulin receptor substrate 1 (Irs1) gene increases survival in …

During aging, the loss of metabolic homeostasis drives a myriad of pathologies. A central
regulator of cellular energy, the AMP-activated protein kinase (AMPK), orchestrates …

Longevity is a defining, heritable trait that varies dramatically between species. To resolve
the genetic regulation of this trait, we have mined genomic variation in rockfishes, which …

Late-life-initiated dietary interventions show limited efficacy in extending longevity or
mitigating frailty, yet the underlying causes remain unclear. Here we studied the age-related …

Metabolic intermediates serve as precursors for bioactive molecule synthesis, the energy
source for life activities, and signals for environmental adaptation. Ketone bodies are …

While previous studies identified common genetic variants associated with longevity in
centenarians, the role of the rare loss-of-function (LOF) mutation burden remains largely …

Longevity is a complex phenotype influenced by both environmental and genetic factors.
The genetic contribution is estimated at about 25%. Despite extensive research efforts, only …