Insulin clearance in health and disease

SM Najjar, S Caprio, A Gastaldelli - Annual Review of …, 2023 - annualreviews.org
Insulin action is impaired in type 2 diabetes. The functions of the hormone are an integrated
product of insulin secretion from pancreatic β-cells and insulin clearance by receptor …

The coexistence of nonalcoholic fatty liver disease and type 2 diabetes mellitus

M Kosmalski, S Ziółkowska, P Czarny… - Journal of Clinical …, 2022 - mdpi.com
The incidence of nonalcoholic fatty liver disease (NAFLD) is growing worldwide.
Epidemiological data suggest a strong relationship between NAFLD and T2DM. This is …

Hepatic insulin extraction in NAFLD is related to insulin resistance rather than liver fat content

KM Utzschneider, SE Kahn… - The Journal of Clinical …, 2019 - academic.oup.com
Context Total insulin clearance is decreased in nonalcoholic fatty liver disease (NAFLD), but
the relationship between liver fat and hepatic insulin extraction (HIE) is unknown. Objective …

A high-risk phenotype associates with reduced improvement in glycaemia during a lifestyle intervention in prediabetes

N Stefan, H Staiger, R Wagner, J Machann, F Schick… - Diabetologia, 2015 - Springer
Aims/hypothesis Lack of reversal of prediabetes (impaired glucose tolerance and/or
impaired fasting glucose) to normal glucose regulation (NGR) during a lifestyle intervention …

[HTML][HTML] Polycystic ovary syndrome as metabolic disease: new insights on insulin resistance

AD Genazzani, AR Genazzani - touchREVIEWS in Endocrinology, 2023 - ncbi.nlm.nih.gov
Polycystic ovary syndrome (PCOS) is a very frequent disease that affects reproductive ability
and menstrual regularity. Other than the criteria established at the Rotterdam consensus, in …

[HTML][HTML] Effects of Yijinjing combined with resistance training on body fat distribution and hepatic lipids in middle-aged and older people with prediabetes mellitus: A …

Y Cai, S Wang, S Wang, Q Gu, Y Huang, J Li… - Experimental …, 2023 - Elsevier
Purpose This randomized controlled trial aimed to study the effects of Yijinjing plus Elastic
Band Resistance exercise on intrahepatic lipid (IHL), body fat distribution, glucolipid …

The associations between liver enzymes and the risk of metabolic syndrome in the elderly

CF Liu, WN Zhou, Z Lu, XT Wang, ZH Qiu - Experimental gerontology, 2018 - Elsevier
Background Studies have demonstrated that liver enzymes are associated with metabolic
syndrome (MetS). However, little information is available regarding these relationships in …

Loss of hepatic CEACAM1: a unifying mechanism linking insulin resistance to obesity and non-alcoholic fatty liver disease

G Heinrich, HE Ghadieh, SS Ghanem… - Frontiers in …, 2017 - frontiersin.org
The pathogenesis of human non-alcoholic fatty liver disease (NAFLD) remains unclear, in
particular in the context of its relationship to insulin resistance and visceral obesity. Work on …

Changes in the leptin to adiponectin ratio are proportional to weight loss after meal replacement in adults with severe obesity

MF Rafey, R Abdalgwad, PM O'Shea, S Foy… - Frontiers in …, 2022 - frontiersin.org
Hypocaloric diets are known to induce changes in adipokine secretion, but the influence of a
low energy liquid diet (LELD) on the leptin: adiponectin ratio (LAR), a measure of insulin …

The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms

S Sarkar, VS Prasanna, P Das, H Suzuki… - Frontiers in …, 2024 - frontiersin.org
Metabolic compromise is crucial in aggravating age-associated chronic inflammation,
oxidative stress, mitochondrial damage, increased LDL and triglycerides, and elevated …