A guide to cell death pathways

J Yuan, D Ofengeim - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

The cell biology of ferroptosis

SJ Dixon, JA Olzmann - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

A guideline on the molecular ecosystem regulating ferroptosis

E Dai, X Chen, A Linkermann, X Jiang, R Kang… - Nature cell …, 2024 - nature.com
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …

Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation

T Nakamura, E Mishima, N Yamada… - Nature Structural & …, 2023 - nature.com
Ferroptosis, marked by iron-dependent lipid peroxidation, may present an Achilles heel for
the treatment of cancers. Ferroptosis suppressor protein-1 (FSP1), as the second ferroptosis …

Lipid quality control and ferroptosis: from concept to mechanism

Z Li, M Lange, SJ Dixon… - Annual Review of …, 2023 - annualreviews.org
Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …

Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - … and Targeted Therapy, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases

J Li, S Zheng, Y Fan, K Tan - Cell Death & Disease, 2023 - nature.com
Kidney diseases remain one of the leading causes of human death and have placed a
heavy burden on the medical system. Regulated cell death contributes to the pathology of a …

Epigenetic modification of ferroptosis by non-coding RNAs in cancer drug resistance

H Wang, JS Fleishman, S Cheng, W Wang, F Wu… - Molecular Cancer, 2024 - Springer
The development of drug resistance remains a major challenge in cancer treatment.
Ferroptosis, a unique type of regulated cell death, plays a pivotal role in inhibiting tumour …

Exceedingly Small Magnetic Iron Oxide Nanoparticles for T1‐Weighted Magnetic Resonance Imaging and Imaging‐Guided Therapy of Tumors

J Yang, J Feng, S Yang, Y Xu, Z Shen - Small, 2023 - Wiley Online Library
Magnetic iron oxide nanoparticles (MIONs) based T2‐weighted magnetic resonance
imaging (MRI) contrast agents (CAs) are liver‐specific with good biocompatibility, but have …

Mechanisms and regulations of ferroptosis

XD Zhang, ZY Liu, MS Wang, YX Guo… - Frontiers in …, 2023 - frontiersin.org
Regulation of cell mortality for disease treatment has been the focus of research. Ferroptosis
is an iron-dependent regulated cell death whose mechanism has been extensively studied …