Lung antimicrobial proteins and peptides: From host defense to therapeutic strategies

YP Di, JM Kuhn, ML Mangoni - Physiological Reviews, 2024 - journals.physiology.org
Representing severe morbidity and mortality globally, respiratory infections associated with
chronic respiratory diseases, including complicated pneumonia, asthma, interstitial lung …

Three innovations of next-generation antibiotics: evolvability, specificity, and non-immunogenicity

H Shim - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance is a silent pandemic exacerbated by the uncontrolled use of
antibiotics. Since the discovery of penicillin, we have been largely dependent on microbe …

Structural Characterization, Cytotoxicity, and the Antifungal Mechanism of a Novel Peptide Extracted from Garlic (Allium sativa L.)

S Li, Y Wang, J Zhou, J Wang, M Zhang, H Chen - Molecules, 2023 - mdpi.com
Garlic (Allium sativa L.) is a traditional plant with antimicrobial activity. This study aimed to
discover new antifungal peptides from garlic, identify their structure, and explore the …

Anti-microbial activity and immunomodulation of recombinant hepcidin 2 and NK-lysin from flounder (Paralichthys olivaceus)

X Li, H Chi, RA Dalmo, X Tang, J Xing, X Sheng… - International Journal of …, 2023 - Elsevier
Infections due to pathogens impact global aquaculture economy, where diseases caused by
bacteria should be in particular focus due to antibiotic resistance. Hepcidin and NK-lysin are …

Strategies for applying probiotics in the antibiotic management of Clostridioides difficile infection

J Yang, L Meng, Y Li, H Huang - Food & Function, 2023 - pubs.rsc.org
The vital role of probiotics in the food field has been widely recognized, and at the same
time, probiotics are gradually exhibiting surprising effects in the field of nutraceuticals …

Anti-Pseudomonas aeruginosa activity of natural antimicrobial peptides when used alone or in combination with antibiotics

X Chen, S Su, Y Yan, L Yin, L Liu - Frontiers in Microbiology, 2023 - frontiersin.org
The World Health Organization has recently published a list of 12 drug-resistant bacteria that
posed a significant threat to human health, and Pseudomonas aeruginosa (P. aeruginosa) …

Characterization of the broad-spectrum antibacterial activity of bacteriocin-like inhibitory substance-producing probiotics isolated from fermented foods

TTD Thuy, HF Lu, CJB Bregente, FCA Huang, PC Tu… - BMC microbiology, 2024 - Springer
Antimicrobial peptides, such as bacteriocin, produced by probiotics have become a
promising novel class of therapeutic agents for treating infectious diseases. Selected lactic …

[HTML][HTML] Biochemistry and Future Perspectives of Antibiotic Resistance: An Eye on Active Natural Products

G Caioni, CP Reyes, D Laurenti, C Chiaradia… - …, 2024 - pmc.ncbi.nlm.nih.gov
Antibiotic resistance poses a serious threat to the current healthcare system, negatively
impacting the effectiveness of many antimicrobial treatments. The situation is exacerbated …

Evaluation of the efficiency of random and diblock methacrylate-based amphiphilic cationic polymers against major bacterial pathogens associated with cystic fibrosis

M Casanova, H Olleik, S Hdiouech, C Roblin… - Antibiotics, 2023 - mdpi.com
Cystic fibrosis (CF) is associated with repeated lung bacterial infection, mainly by
Pseudomonas aeruginosa, Staphylococcus aureus, and Mycobacterium abscessus, all …

Microbiome-derived antimicrobial peptides show therapeutic activity against the critically important priority pathogen, Acinetobacter baumannii

PJ Alexander, LB Oyama, H Olleik… - npj Biofilms and …, 2024 - nature.com
Acinetobacter baumannii is designated by the World Health Organisation as a critical priority
pathogen. Previously we discovered antimicrobial peptides (AMPs), namely Lynronne-1,-2 …