Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation,
autoimmune diseases, and cancer. To exert their broad physiological and therapeutic …

Glucocorticoids (GCs) have been used clinically for decades as potent anti-inflammatory
and immunosuppressive agents. Nevertheless, their use is severely hampered by the risk of …

The clinical use of classical glucocorticoids (GC) is narrowed by the many side effects it
causes and the resistance to GC observed in some diseases. Since the great majority of GC …

Adrenal glucocorticoid hormones are crucial for maintenance of homeostasis and
adaptation to stress. They act via the mineralocorticoid receptors (MRs) and glucocorticoid …

For many decades, glucocorticoids have been widely used as the gold standard treatment
for inflammatory conditions. Unfortunately, their clinical use is limited by severe adverse …

Glucocorticoids (GCs; referred to clinically as corticosteroids) are steroid hormones with
potent anti-inflammatory and immune modulatory profiles. Depending on the context, these …

The glucocorticoid hormone cortisol acts throughout the body to support circadian processes
and adaptation to stress. The glucocorticoid receptor is the target of cortisol and of synthetic …

For over 70 years, the unique anti-inflammatory properties of glucocorticoids (GCs), which
mediate their effects via the ligand-activated transcription factor, the glucocorticoid receptor …

The endothelium plays a crucial role in inflammation. A balanced control of inflammation
requires the action of glucocorticoids (GCs), steroidal hormones with potent cell-specific anti …

Glucocorticoid hormones (GCs) have profound effects on bone metabolism. Via their nuclear
hormone receptor–the GR–they act locally within bone cells and modulate their proliferation …