Improved understanding of differences in kidney disease epidemiology, management and
outcomes in men and women could help nephrologists to better meet the needs of their …

Background In patients with normal renal function or early stage CKD, the risk-benefit profile
of direct oral anticoagulants (DOACs) is superior to that of vitamin K antagonists (VKAs). In …

Rates of thrombosis and bleeding episodes are both increased in patients with advanced
chronic kidney disease (CKD). The pathogenic mechanisms of thrombosis in these patients …

In the absence of robust evidence to guide clinical decision-making, the optimal approach to
prevent stroke and systemic embolism in haemodialysis (HD) patients with atrial fibrillation …

The objective of this study was to investigate whether the improvement in survival seen in
patients on kidney replacement therapy reflects the enhanced survival of the general …

Background Cardiovascular diseases are the dominant cause of morbidity in hemodialysis
(HD) patients. Unless sufficient anticoagulation is used during HD, clotting may appear. The …

Age-associated deterioration of physiological functions occur at heterogeneous rates across
individual organs. A granular evaluation of systemic metabolic mediators of aging in a …

Rationale & Objective The risks of major bleeding, thrombosis, and cardiovascular events
are elevated in patients receiving maintenance hemodialysis (HD). Our objective was to …

Despite the proven superiority of the Chronic Kidney Disease Epidemiology Collaboration
(CKD-EPI) over the Cockcroft–Gault (CG) formula, current guidelines recommend the latter …

Coagulation abnormalities are common in chronic kidney disease (CKD). Tissue factor (TF,
factor III) is a master regulator of the extrinsic coagulation system, activating downstream …