Innovations and advances in modelling and measuring pain in animals
Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …
decade as a result of technological advancements, the continued dearth of translational …
Current EU regulatory requirements for the assessment of chemicals and cosmetic products: challenges and opportunities for introducing new approach …
F Pistollato, F Madia, R Corvi, S Munn, E Grignard… - Archives of …, 2021 - Springer
Abstract The EU Directive 2010/63/EU on the protection of animals used for scientific
purposes and other EU regulations, such as REACH and the Cosmetic Products Regulation …
purposes and other EU regulations, such as REACH and the Cosmetic Products Regulation …
Developing nociceptor-selective treatments for acute and chronic pain
Despite substantial efforts dedicated to the development of new, nonaddictive analgesics,
success in treating pain has been limited. Clinically available analgesic agents generally …
success in treating pain has been limited. Clinically available analgesic agents generally …
[HTML][HTML] Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC)-derived sensory neurons
Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent, potentially irreversible
adverse effect of cytotoxic chemotherapy often leading to a reduction or discontinuation of …
adverse effect of cytotoxic chemotherapy often leading to a reduction or discontinuation of …
Molecular and functional characterization of neurogenin-2 induced human sensory neurons
Sensory perception is fundamental to everyday life, yet understanding of human sensory
physiology at the molecular level is hindered due to constraints on tissue availability …
physiology at the molecular level is hindered due to constraints on tissue availability …
Satellite glial cells give rise to nociceptive sensory neurons
D Wang, J Lu, X Xu, Y Yuan, Y Zhang, J Xu… - Stem cell reviews and …, 2021 - Springer
Dorsal root ganglia (DRG) sensory neurons can transmit information about noxious stimulus
to cerebral cortex via spinal cord, and play an important role in the pain pathway. Alterations …
to cerebral cortex via spinal cord, and play an important role in the pain pathway. Alterations …
NOCICEPTRA: gene and microRNA signatures and their trajectories characterizing human iPSC‐derived nociceptor maturation
Nociceptors are primary afferent neurons serving the reception of acute pain but also the
transit into maladaptive pain disorders. Since native human nociceptors are hardly available …
transit into maladaptive pain disorders. Since native human nociceptors are hardly available …
Sickle cell disease iPSC-derived sensory neurons exhibit increased excitability and sensitization to patient plasma
Individuals living with sickle cell disease (SCD) experience severe recurrent acute and
chronic pain. Challenges to gaining mechanistic insight into pathogenic SCD pain …
chronic pain. Challenges to gaining mechanistic insight into pathogenic SCD pain …
NOCICEPTRA2. 0-a comprehensive ncRNA atlas of human native and iPSC-derived sensory neurons
Non-coding RNAs (ncRNAs) are pivotal in gene regulation during development and
disease. MicroRNAs have been extensively studied in neurogenesis. However, limited …
disease. MicroRNAs have been extensively studied in neurogenesis. However, limited …
Towards bridging the translational gap by improved modeling of human nociception in health and disease
Despite numerous studies which have explored the pathogenesis of pain disorders in
preclinical models, there is a pronounced translational gap, which is at least partially caused …
preclinical models, there is a pronounced translational gap, which is at least partially caused …