Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …

The altered activation or overexpression of protein kinases (PKs) is a major subject of
research in oncology and their inhibition using small molecules, protein kinases inhibitors …

CDK2 inhibition is an appealing target for cancer treatment that targets tumor cells in a
selective manner. A new set of small molecules featuring the privileged pyrazolo [3, 4-d] …

In the current study, novel pyrazolo [3, 4-d] pyrimidine derivatives 5a–h were designed and
synthesized as targeted anti-cancer agents through dual CDK2/GSK-3β inhibition. The …

The use of mixed oxides is a well-appreciated approach in the fields of material science and
synthesis, due to remarkable tunable surface properties such as acidic and basic …

Abstract New 1 H-pyrazolo [3, 4-d] pyrimidine derivatives were designed and synthesised to
act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives …

Cyclin-dependent kinase inhibition is considered a promising target for cancer treatment for
its crucial role in cell cycle regulation. Pyrazolo pyrimidine derivatives were well established …

Pyrazolo [3, 4-d] pyrimidines have become of significant interest for the medicinal chemistry
community as a privileged scaffold for the development of kinase inhibitors to treat a range …

Abstract Fused pyrimidines, especially pyrazolo [3, 4‐d] pyrimidines, are among the most
preferred building blocks for pharmacology studies, as they exhibit a broad spectrum of …

A series of new pyrazolo [3, 4-d] pyrimidine possessing 4-(1H-benzimidazol-2-yl)-
phenylamine moiety at C4 position and primary as well as secondary amines at C6 position …