Two hormones for one receptor: evolution, biochemistry, actions, and pathophysiology of LH and hCG

L Casarini, D Santi, G Brigante, M Simoni - Endocrine reviews, 2018 - academic.oup.com
LH and chorionic gonadotropin (CG) are glycoproteins fundamental to sexual development
and reproduction. Because they act on the same receptor (LHCGR), the general consensus …

Short-term effects of metformin and myo-inositol in women with polycystic ovarian syndrome (PCOS): a meta-analysis of randomized clinical trials

F Facchinetti, B Orru, G Grandi… - Gynecological …, 2019 - Taylor & Francis
Metformin (MET), the most commonly used insulin sensitizer, is the reference off-label drug
for the treatment of polycystic ovary syndrome (PCOS), worldwide. However, its use may be …

Pregnancy in women with thalassemia: challenges and solutions

G Petrakos, P Andriopoulos… - International journal of …, 2016 - Taylor & Francis
Advances in treatment of thalassemia have led to the aging of thalassemic patients, and
consequently concern about successful reproductive outcome is augmented. Although …

The freeze-all strategy after IVF: which indications?

M Bourdon, C Maignien, K Pocate-Cheriet… - Reproductive …, 2021 - Elsevier
The freeze-all strategy is gaining popularity worldwide as an alternative to the conventional
fresh embryo transfer. It consists of cryopreservation of the entire embryo cohort and the …

[HTML][HTML] Pregnancy in thalassemia

R Origa, F Comitini - … journal of hematology and infectious diseases, 2019 - ncbi.nlm.nih.gov
Therapeutic advances, including the availability of oral iron chelators and new non-invasive
methods for early detection and treatment of iron overload, have significantly improved the …

The role of Letrozole (LE) in controlled ovarian stimulation (COS) in patients at high risk to develop ovarian hyper stimulation syndrome (OHSS). A prospective …

R Tshzmachyan, E Hambartsoumian - Journal of Gynecology Obstetrics …, 2020 - Elsevier
Background Recently, it has been shown that PCOS patients with extremely high anti-
Mullerian hormone (AMH) level are more likely to experience OHSS during IVF, compared to …

Sliding scale HCG trigger yields equivalent pregnancy outcomes and reduces ovarian hyperstimulation syndrome: analysis of 10,427 IVF-ICSI cycles

V Gunnala, A Melnick, M Irani, D Reichman… - PLoS …, 2017 - journals.plos.org
Objective To evaluate pregnancy outcomes and the incidence of ovarian hyperstimulation
syndrome (OHSS) using a sliding scale hCG protocol to trigger oocyte maturity and establish …

[HTML][HTML] Individualization of the starting dose of follitropin delta reduces the overall OHSS risk and/or the need for additional preventive interventions: cumulative data …

M Fernández-Sánchez, H Visnova, A Yuzpe… - Reproductive …, 2019 - Elsevier
Research question Is individualization of dosing with follitropin delta in sequential ovarian
stimulation cycles an effective preventive strategy for ovarian hyperstimulation syndrome …

Upregulation of AREG, EGFR, and HER2 contributes to increased VEGF expression in granulosa cells of patients with OHSS

L Fang, Y Yu, Y Li, S Wang, J He, R Zhang… - Biology of …, 2019 - academic.oup.com
Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic complication in women
undergoing induction of ovulation with human chorionic gonadotropin (hCG) for assisted …

Follicle-stimulating hormone receptor: advances and remaining challenges

F De Pascali, A Tréfier, F Landomiel, V Bozon… - International review of …, 2018 - Elsevier
Follicle-stimulating hormone (FSH) is produced in the pituitary and is essential for
reproduction. It specifically binds to a membrane receptor (FSHR) expressed in somatic cells …