Obesity and asthma
S Miethe, A Karsonova, A Karaulov, H Renz - Journal of Allergy and …, 2020 - Elsevier
Obesity has been well recognized as an important comorbidity in patients with asthma,
representing a unique phenotype and endotype. This association indicates a close …
representing a unique phenotype and endotype. This association indicates a close …
Toxic dimethylarginines: asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA)
Asymmetric and symmetric dimethylarginine (ADMA and SDMA, respectively) are toxic, non-
proteinogenic amino acids formed by post-translational modification and are uremic toxins …
proteinogenic amino acids formed by post-translational modification and are uremic toxins …
Asthma and three colinear comorbidities: obesity, OSA, and GERD
Asthma is a complex disease with heterogeneous phenotypes and endotypes that are
incompletely understood. Obesity, obstructive sleep apnea, and gastroesophageal reflux …
incompletely understood. Obesity, obstructive sleep apnea, and gastroesophageal reflux …
Asthma and obesity: mechanisms and clinical implications
CW Baffi, DE Winnica, F Holguin - Asthma research and practice, 2015 - Springer
Obesity is the most common asthma co-morbidity; it has been associated with increased risk
for asthma exacerbations, worse respiratory symptoms and poor control. The exact …
for asthma exacerbations, worse respiratory symptoms and poor control. The exact …
An Association between l-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype
Rationale: Increasing body mass index (BMI) has been associated with less fractional
exhaled nitric oxide (FeNO). This may be explained by an increase in the concentration of …
exhaled nitric oxide (FeNO). This may be explained by an increase in the concentration of …
Emerging comorbidities in adult asthma: risks, clinical associations, and mechanisms
H Kankaanranta, P Kauppi, LE Tuomisto… - Mediators of …, 2016 - Wiley Online Library
Asthma is a heterogeneous disease with many phenotypes, and age at disease onset is an
important factor in separating the phenotypes. Most studies with asthma have been …
important factor in separating the phenotypes. Most studies with asthma have been …
VMA21 deficiency prevents vacuolar ATPase assembly and causes autophagic vacuolar myopathy
N Ramachandran, I Munteanu, P Wang, A Ruggieri… - Acta …, 2013 - Springer
X-linked Myopathy with Excessive Autophagy (XMEA) is a childhood onset disease
characterized by progressive vacuolation and atrophy of skeletal muscle. We show that …
characterized by progressive vacuolation and atrophy of skeletal muscle. We show that …
Arginine therapy for lung diseases
JA Scott, H Maarsingh, F Holguin… - Frontiers in …, 2021 - frontiersin.org
Nitric oxide (NO) is produced by a family of isoenzymes, nitric oxide synthases (NOSs),
which all utilize l-arginine as substrate. The production of NO in the lung and airways can …
which all utilize l-arginine as substrate. The production of NO in the lung and airways can …
Bioenergetic Differences in the Airway Epithelium of Lean Versus Obese Asthmatics Are Driven by Nitric Oxide and Reflected in Circulating Platelets
D Winnica, C Corey, S Mullett, M Reynolds… - Antioxidants & redox …, 2019 - liebertpub.com
Aims: Asthma, characterized by airway obstruction and hyper-responsiveness, is more
severe and less responsive to treatment in obese subjects. While alterations in …
severe and less responsive to treatment in obese subjects. While alterations in …
Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress
J Gao, T Lei, H Wang, K Luo, Y Wang, B Cui… - Particle and Fibre …, 2022 - Springer
Background Airborne fine particulate matter with aerodynamic diameter≤ 2.5 μm (PM2. 5)
pollution is associated with the prevalence of respiratory diseases, including asthma …
pollution is associated with the prevalence of respiratory diseases, including asthma …